kugler, jan-michael – University of Copenhagen

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Department of Cellular and Molecular Medicine > icmm-staff > kugler, jan-michael

Jan-Michael Kugler

assistant professor


room: 18.4.48
telephone: (+45) 21 17 95 71 / 35 32 73 06

e-mail: jmkugler@sund.ku.dk

 

Keywords: Translational Cancer Research, Genetic Models of Metastasis, Cancer Cell Metabolism. 

 

research group 

 

 

Research interests
I am broadly interested in the molecular and cellular mechanisms that leads to malignant transformation of cancer cells. I am using an invertebrate model organism – the fruit fly Drosophila – as a discovery platform to identify novel genes involved in metastasis development. I am using mammalian cell culture models to explore whether the function of candidate genes may be conserved and hence potentially relevant to human cancers.

Current Project Areas
Currently, I am investigating ubiquitin-dependent regulation of a well-known tumor suppressor gene by a deubiquitinating enzyme. Moreover, I am investigating a novel metabolic enzyme whose depletion causes cancer-like phenotypes both in the fly and in cultured human cells.