cohen, stephen – University of Copenhagen

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Department of Cellular and Molecular Medicine > icmm-staff > cohen, stephen

Stephen cohen

Stephen Cohen

Professor

Mobile: (+45) 51 29 79 67

Telephone: (+45) 35 32 73 26
Room: 18.4.42
E. mail: scohen@sund.ku.dk 

 

Research Interests

microRNA functions in development and disease, using Drosophila.

Current Project Areas

Genetic models of oncogene cooperation.
microRNAs and neurodegeneration.
microRNAs and stem cells.
microRNAs and metabolism. 
DISC-B: Denmark-India in vivo Screen for Cancer Biomarkers

Selected Publications

Chen Y-W, Song, S., Weng, R., Verma, P., Kugler, J.-M., Buescher, M., Rouam, S., & Cohen, S.M. (2014). Systematic study of Drosophila microRNA functions using a collection of targeted knockout mutations. Dev Cell, in press DOI: 10.1016/j.devcel.2014.11.029

Foronda, D., Weng, R., Verma, P., Chen. Y.-W. & Cohen S.M. (2014) Coordination of Insulin and Notch pathway activities by microRNA miR-305 mediates adaptive homeostasis in the intestinal stem cells of the Drosophila gut. Genes Dev 28: 2421-2431. DOI: 10.1101/gad.241588.114

Hong, X., Nguyen H.T., Chen Q., Zhang, R., Hagman, Z., Voorhoeve, P.M. & Cohen, S.M. (2014). Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover. EMBO J DOI: 10.15252/embj.201489385  

Nguyen H.T., Hong, X., Tan, S., Chen Q., Chan,L., Fivaz.M., Cohen, S.M. & Voorhoeve, P.M. (2014) Viral small T oncoproteins transform cells by alleviating Hippo pathway-mediated inhibition of the YAP proto-oncogene. Cell Reports 8, 707-713. doi: 10.1016/j.celrep.2014.06.062

Herranz, H., Weng, R., & Cohen, S.M. (2014) Cross-talk between epithelial and mesenchymal tissues in tumorigenesis and imaginal disc development. Current Biology 24, 1476–1484.
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Zhang, W., Hietakangas,V., Wee, S.,  Lim, R.  Gunaratne, J., and Cohen, S.M.  (2013) ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation. Genes Dev 27(4):441-9

Herranz, H., Hong, X., Nguyen T.H., Voorhoeve, P.M. and Cohen, S.M.  (2012) Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model. Genes Dev 26, 1602-1611.

Herranz, H., Hong, X., and Cohen, S.M.  (2012) Mutual repression by bantam miRNA and Capicua links the EGFR/MAPK and Hippo pathways in growth control. Current Biology. 22, 651-657

Varghese, J., Lim, S., and SM Cohen (2010) Drosophila miR-14 regulates insulin production and metabolism through its target sugarbabe. Genes Dev. 24: 2748-2753.

Herranz, H. and SM Cohen (2010) microRNAs and gene regulatory networks: managing the impact of noise in biological systems. Genes Dev 24, 1339-1344

Hong, X., Hammell, M. Ambros, V and Cohen, S.M. (2009) Identification of microRNA targets by immunopurification of Ago1 RNPs: selection for a distinct class of targets. PNAS 106, 15085-90.

Bushati, N., Stark, A., Brennecke, J., and Cohen, S.M. (2008) Temporal reciprocity of microRNAs and their targets during the maternal to zygotic transition in Drosophila. Current Biology 18, 501-506.

J Karres, V Hilgers, I Carrera, J Treisman & SM Cohen (2007) The conserved microRNA miR-8 tunes Atrophin levels to prevent neurodegeneration in Drosophila. Cell 131, 136–145.

BJ Thompson & SM Cohen  (2006) The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila. Cell.126, 767-774.

Stark, A., Brennecke, J., Bushati, N. Russell, R.B. & Cohen, S.M. (2005) Animal microRNAs confer robustness to gene expression and have a significant impact on 3’UTR evolution. Cell 123,1133-1146.

Brennecke, J., Hipfner, D.R. Stark, A., Russell, R & Cohen, S.M. (2003) bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the pro-apoptotic gene hid in Drosophila. Cell 113: 25-36.