Bentin Group – University of Copenhagen

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Department of Cellular and Molecular Medicine > Research Groups > Bentin Group

Bentin Group

RNA and Gene Medicine Program
Molecular Aging Program

Research Interests

Recently, we initiated work in the field of chromosome biology. We have developed novel chromosome locus-specific live-cell imaging technology using Cas9 derivatives. We aim to observe how certain conditions impact specific human chromosomal loci. We hope to generate a deeper understanding of chromosome dynamics and in particular of cancer-associated loci. This work is a collaboration with Ian D. Hickson and the Center for Chromosome Stability.

Previously, we discovered how chaperonins impact bacterial resistance to translation corrupting antibiotics. We have uncovered criteria for engineering of mRNAs with predictable translation outputs. Using mutant aminoacyl-tRNA synthetases, we introduced synthetic photo-reactive amino acid into the genetic code of E. coli. We engineered a novel GFP variant aiming to develop a reporter for translational fidelity. We studied how DNA topology impact mRNA transcription and peptide nucleic acid binding to dsDNA.

Teaching

I teach cell biology and molecular biology for medical students, and other students. I also mentor bachelors, masters and/or Ph.D. students doing their research projects. I think a broad research background plays a positive role in my teaching

Recent publications

  • Thomas Bentin. CRISPR highlights and transition of Cas9 into genome editing tool.  Royal Society of Chemistry. DNA-Targeting Molecules as Therapeutic Agents, edited by Michael Waring (book chapter, in press) 2017.

  • Kantaraja Chindera, Ashwani Kumar Sharma, Manohar Mahato, Harry Horsely, Klaudia Kloc-Muniak, Jem Stach, Thomas Bentin, and Liam Good.  PHMB enters cells and kills bacteria via selective chromosome condensation. Scientific Reports 2016 Mar 21;6:23121

  • Lise Goltermann, Viktor Menachem Sarusie, and Thomas Bentin. Chaperonin GroEL/GroES over-expression promotes multi-drug resistance in E. coli following exposure to aminoglycoside antibiotics, Frontiers in Microbiology, 2016 Jan 26;6:1572

  • Mette Thorsing, Thomas Bentin, Michael Givskov, Tim Tolker-Nielsen, Lise Goltermann. (2015) The bactericidal activity of beta-lactam antibiotics is increased by metabolizable sugar species. Microbiology, 161, 1999-2007.