publications – University of Copenhagen

Mansour Akbari


29. Sykora P, Kanno S, Akbari M, Kulikowicz T, Baptiste BA, Leandro GS, Lu H, Tian J, May A, Becker KA, Croteau DL, Wilson DM 3rd, Sobol RW, Yasui A, Bohr VA. DNA polymerase beta participates in mitochondrial DNA repair. Mol Cell Biol. 2017 May 30. pii: MCB.00237-17.

28. Hou Y, Song H, Croteau DL, Akbari M, Bohr VA Genome instability in Alzheimer disease. Mech Ageing Dev. 2016 Apr 19. pii: S0047-6374(16)30047-1

27. Akbari M, Sykora P, Bohr VA. Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells. Sci Rep. 2015 Aug 10;5:12876.

26. Akbari M, Morevati M, Croteau D, Bohr VA. The role of DNA base excision repair in brain homeostasis and disease.  DNA Repair (Amst). 2015 May 1. pii: S1568-7864(15)00121-4.

25. Mansour Akbari, Guido Keijzers, Scott Maynard, Morten Scheibye-Knudsen, Claus Desler, Ian D. Hickson, Vilhelm A. Bohr. Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair.
DNA Repair, 16 (2014) 44–53.

24. Akbari, M & Krokan, HE 2012, 
Base excision repair efficiency and mechanism in nuclear extracts are influenced by the ratio between volume of nuclear extraction buffer and nuclei-Implications for comparative studies                        
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol 736, nr. 1-2, s. 33-38.

23. Hanssen-Bauer A, Solvang-Garten K, Akbari M, Otterlei M. X-ray repair cross complementing protein 1 in base excision repair. Int. J. Mol. Sci. 2012; 17;13(12):17210-29.

22. Deborah L. Croteau, Marie L. Rossi, Chandrika Canugovi, Jane Tian, Peter Sykora,Mahesh Ramamoorthy, ZhengMing Wang, Dharmendra Kumar Singh, Mansour Akbari, Rajesh Kasiviswanathan, William C. Copeland, Vilhelm A. Bohr. RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity. Aging cell, Feb. 2012.

21. Audun Hanssen-Bauer, Karin Solvang-Garten, Karin Margaretha Gilljam, Kathrin Thorseth, David M. Wilson III, Mansour Akbari and Marit Otterlei. The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1. DNA repair, Jan. 2012.

20. Wollen Steen K, Doseth B, P Westbye M, Akbari M, Kang D, Falkenberg M, Slupphaug G. mtSSB may sequester UNG1 at mitochondrial ssDNA and delay uracil processing until the dsDNA conformation is restored. DNA repair Jan. 2012.

19.  Hanssen-Bauer A, Solvang-Garten K, Sundheim O, Peña-Diaz J, Andersen S, Slupphaug G, Krokan HE, Wilson DM 3rd, Akbari M, Otterlei M.XRCC1 coordinates disparate responses and multi-protein repair complexes depending on the nature and context of the DNA damage. Environ. Mol. Mutagen. Jul. 2011.

18.  Akbari M, Krokan HE. Base excision repair efficiency and mechanism in nuclear extracts are influenced by the ratio between volume of nuclear extraction buffer and nuclei-Implications for comparative studies. Mutat. Res. Jun 2011.

17Akbari M, Solvang-Garten K, Hanssen-Bauer A, Lieske NV, Pettersen HS, Pettersen GK, Wilson DM 3rd, Krokan HE, Otterlei M. Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes. DNA Repair. 9(2010):785-95.

16.  Akbari M, Peña-Diaz J, Andersen S, Liabakk NB, Otterlei M, Krokan HE. Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity. DNA Repair. 7(2009):834-43.

15.  Visnes T, Doseth B, Pettersen HS, Hagen L, Sousa MM, Akbari M, Otterlei M, Kavli B, Slupphaug G, Krokan HE. Uracil in DNA and its processing by different DNA glycosylases. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 2009, 364(1517):563-8. Review.

14.  Visnes T, Akbari M, Hagen L, Slupphaug G, Krokan HE. The rate of base excision repair of uracil is controlled by the initiating glycosylase. DNA Repair. 7(2008):1869-81.

13.  Westbye MP, Feyzi E, Aas PA, Vågbø CB, Talstad VA, Kavli B, Hagen L, Sundheim O, Akbari M, Liabakk NB, Slupphaug G, Otterlei M, Krokan HE. Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. J. Biol. Chem. 2008;283(36):25046-56.

12. Akbari M, Krokan HE. Cytotoxicity and mutagenicity of endogenous DNA base lesions as potential cause of human aging. Mech Ageing Dev. 2008,129(7-8):353-65.

11.  Akbari M, Visnes T, Krokan HE, Otterlei M. Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis. DNA Repair. 7(2008):605-16.

10.  Akbari M, Otterlei M, Peña-Diaz J, Krokan HE. Different organization of base excision repair of uracil in DNA in nuclei and mitochondria and selective upregulation of mitochondrial uracil-DNA glycosylase after oxidative stress. Neuroscience. 2007, 145(4):1201-12.

9.  Akbari M, Hansen MD, Halgunset J, Skorpen F, Krokan HE. Low copy number DNA template can render polymerase chain reaction error prone in a sequence-dependent manner. J. Mol. Diagn. 2005, 7(1):36-9.

8.  Akbari M, Otterlei M, Peña-Diaz J, Aas PA, Kavli B, Liabakk NB, Hagen L, Imai K, Durandy A, Slupphaug G, Krokan HE. Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells. Nucleic Acids Res. 2004, 32(18):5486-98.

7.  Peña-Diaz J, Akbari M, Sundheim O, Farez-Vidal ME, Andersen S, Sneve R, Gonzalez-Pacanowska D, Krokan HE, Slupphaug G. Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair. J. Mol. Biol. 2004, 17;342(3):787-99.

6Akbari M, Skjelbred C, Følling I, Sagen J, Krokan HE. A gel electrophoresis method for detection of mitochondrial DNA mutation (3243 tRNA(Leu (UUR))) applied to a Norwegian family with diabetes mellitus and hearing loss. Scand. J. Clin. Lab. Invest. 2004, 64(2):86-92.

5.  Aas PA, Otterlei M, Falnes PO, Vågbø CB, Skorpen F, Akbari M, Sundheim O, Bjørås M, Slupphaug G, Seeberg E, Krokan HE. Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. Nature. 2003, 421(6925):859-63.

4.  Kavli B, Sundheim O, Akbari M, Otterlei M, Nilsen H, Skorpen F, Aas PA, Hagen L, Krokan HE, Slupphaug G. hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup. J Biol Chem. 2002, 277(42):39926-36.

3.  Krokan HE, Otterlei M, Nilsen H, Kavli B, Skorpen F, Andersen S, Skjelbred C, Akbari M, Aas PA, Slupphaug G. Properties and functions of human uracil-DNA glycosylase from the UNG gene. Prog. Nucleic Acid Res. Mol. Biol. 2001;68:365-86. Review.

2.  Kvaløy K, Nilsen H, Steinsbekk KS, Nedal A, Monterotti B, Akbari M, Krokan HE. Sequence variation in the human uracil-DNA glycosylase (UNG) gene. Mutat Res. 2001, 5;461(4):325-38.

1.  Otterlei M, Warbrick E, Nagelhus TA, Haug T, Slupphaug G, Akbari M, Aas PA, Steinsbekk K, Bakke O, Krokan HE. Post-replicative base excision repair in replication foci. EMBO J. 1999;18(13):3834-44.