publications – University of Copenhagen

Henrik Clausen


190 original papers, 23 reviews and book chapters, 24 issued US patents

(h value 54)

Original publications in peer reviewed international journals 

1.  Clausen H, Vedtofte P, Moe D, Dabelsteen E (1983).  Keratin pattern in human oral buccal and hard palate mucosa.  Scand J Dent Res 91: 411‑413.

2.  Clausen H, Watanabe K, Kannagi R, Levery SB, Nudelman E, Arao‑Tomo­no Y, Hakomori S (1984).  Blood group A glycolipid (Ax) with globo‑series structure which is specific for blood group A1 erythrocytes:  One of the chemical bases for A1 and A2 distinction. Biochem Biophys Res Commun 124: 523‑529.

3.  Clausen H, Levery SB, McKibbin JM, Hakomori S (1985). Blood group A determinants with mono‑ and difucosyl type 1 chain in human erythrocyte membranes. Biochemistry 24: 3578‑3586.

4.  Clausen H, McKibbin JM, Hakomori S (1985).  Monoclonal antibodies defining blood group A variants with difucosyl type 1 chain (ALeb) and difucosyl type 2 chain (ALey).  Biochemistry 24: 6190‑6194.

5.  Clausen H, Levery SB, Nudelman E, Tsuchiya S, Hakomori S (1985).  Novel repetitive A epitope (type 3 chain A) defined by blood group A1‑specific monoclo­nal antibody TH‑1:  A chemical basis of qualitative A1 and A2 distinc­tion.  Proc Natl Acad Sci USA 82:1199‑1203.

6.  Furukawa K, Clausen H, Hakomori S, Sakamoto J, Losk K, Lundblad A, Mattes MJ, Lloyd KO (1985).  Analysis of the specificity of five murine anti‑­blood group A monoclonal antibodies, including one that identifies type 3 and 4 A determinants.  Biochemistry 24: 7802‑7826.

7.  Hirohashi S, Clausen H, Yamada T, Shimosata Y, Hakomori S (1985).  Blood group A cross‑reacting epitope defined by monoclonal antibodies NCC‑Lu‑35 and ‑81 expressed in cancer of blood group O or B individuals:  Its iden­tifica­tion as Tn antigen.  Proc Natl Acad Sci USA 82: 7039‑7043.

8.  Reibel J, Clausen H, Dabelsteen E (1985).  Keratins in premalignant oral lesions.  Acta Path Microbiol Scand Sect A 93:323-330.

9.  Clausen H, Hakomori S, Graem N, Dabelsteen E (1986).  Incompatible A antigen expressed in tumors of blood group O and B individuals:  Im­muno­chemical, immunohistological, and enzymatic characterization.  J Immunol 136: 326‑330.

10.  Clausen H, Vedtofte P, Moe D, Dabelsteen E, Sun T‑T, Dale B (1986).  Differentia­tion‑depen­dent expression of keratins in human oral epithelia.  J Invest Dermatol 86: 249‑254.

11.  Clausen H, Levery SB, Kannagi R, Hakomori S (1986).  Novel blood group H glycolipid antigens exclusively expressed in blood group A and AB ery­th­rocytes (type 3 chain H):  I.  Isolation and chemical characteriza­tion.  J Biol Chem 261: 1380‑1387.

12.  Clausen H, Holmes E, Hakomori S (1986).  Novel blood group H glycolipid antigens ex­clusively expressed in blood group A and AB erythrocytes (type 3 chain H):  II.  Differential conversion of different H substrates by A1 and A2 enzymes, and type 3 chain H expression in relation to secretor status.  J Biol Chem 261: 1388‑1392.

13.  Clausen H, Levery SB, Nudelman E, Baldwin M, Hakomori S (1986).  Further characterization of type 2 and type 3 chain blood group A glycosphingo­lipids from human  erythrocyte membranes.  Biochemistry 25: 7075‑7085.

14.  Clausen H, Moe D, Buschard K, Dabelsteen E (1986).  Keratin proteins in human oral mucosa.  J Oral Path 15: 36‑42.

15.  Dabelsteen E, Holbrook K, Clausen H, Hakomori S (1986).  Cell surface car­bohydrate changes during embryonic and fetal skin development.  J Invest Dermatol 87: 81‑85.

16.  Fenderson BA, Nichols EJ, Clausen H, Hakomori S (1986). A  monoclonal antibody defining a binary N‑acetyllactosaminyl structure in lactoiso­octaosyl­ceramide (IV6Galß1b4GlcNAc2nLc6):  A useful probe for determining differen­tial glycosylation patterns between normal and transfor­med human fibro­blasts.  Molecular Immunology 23: 747‑754. 

17.  Hirohashi S, Clausen H, Nudelman E, Inoue H, Shimosato Y, Hakomori S (1986). A human monoclonal antibody directed to blood group i antigen:  Heterohybrido­ma between human lymphocytes from regional lymph nodes of a lung cancer patient and mouse myeloma.  J Immunol 136: 4163‑4168.

18.  Jacewicz M, Clausen H, Nudelman E, Donohue‑Rolfe A, Keusch GT (1986). Pathogenesis of Shigella diarrhea:  XI.  Isolation of a Shigella toxin‑binding glycolipid from rabbit jejunum and HeLa cells and its identification as globotria­o­sylceramide.  J Exp Med 163: 1391‑1404.

19.  Fenderson BA, Andrews PW, Nudelman E, Clausen H, Hakomori S (1987).  Core structure switching of glycolipids from globo‑ to lacto‑ and ganglio‑se­ries during retinoic acid‑induced differentiation of TERA‑2‑derived human em­bryonal carcinoma cells.  Dev Biol 122: 21‑34.

20.  Holmes EH, Ostrander GO, Clausen H, Graem N (1987).  Oncofetal expres­sion of Lex carbohydrate antigens in human colonic adenocarci­noma:  Regula­tion through type 2 core chain synthesis rather than fucosylation.  J Biol Chem 262:11331-11338.

21.  Ørntoft T, Wolf H, Clausen H, Hakomori S, Dabelsteen E (1987).  Blood group ABO and Lewis antigens in fetal and normal adult bladder urothelium:  Im­munohistochemical study of type 1 chain structures.  J Urol 138: 171-176.

22.  Clausen H, Levery SB, Salyan MEK, Nudelman ED, Stroud M, Hakomori S (1987).  Isolation and characterization of novel glycolipids with blood group A‑related structures.  J Biol Chem 262:14228-14234.

23.  Ørntoft T, Nielsen MJS, Wolf H, Olsen S, Clausen H, Hakomori S, Dabel­steen E (1988). Blood group ABO and Lewis antigen expression during neoplastic progression of human urothelium: Immunohisto­chemical study of type 1 chain structures. Cancer 60:181-187.

24.  Clausen H, Stroud M, Parker J, Hakomori S (1988).  Monoclonal antibodies directed to the blood group A associated structure, galac­tosyl‑A:  Specificity and relation to the Thomsen‑­Friedenreich antigen.  Mol Immunol 25:199-204.

25.  Dabelsteen E, Graem N, Clausen H, Hakomori S (1988).  Structural varia­tions of blood group A antigens in human normal colon and carcinomas. Cancer Res 48:181-187.

26.  Kjeldsen T, Clausen H, Hirohashi S, Ogawa T, Iijima H, Hakomori S (1988). Preparation and characterization of tumor-associated monoclonal antibodies directed to the O-linked sialosyl-2-6 a-N-acetylgalactos­aminyl (sialosyl-Tn) epitope. Cancer Res 48:2214-2220.

27.  Levery SB, Nudelman ED, Kannagi R, Symington FW, Andersen NH, Clausen H, Baldwin M, Hakomori S (1988).  1H‑NMR analysis of type 2 chain lac­to‑series gangliosides: Confirmation of structure of a novel can­cer‑associated fucoganglio­side, VI6NeuAcIII3FucnLc6Cer.  Carbohydr Res 178:121-141.

28.  Ørntoft T, Wolf H, Clausen H, Dabelsteen E, Hakomori S (1988). Blood group ABO related antigens in fetal and normal adult bladder urothelium: Immunohis­tochemical study of type 2 chain structures with a panel of mouse monoclonal antibodies. Lab Invest 58:576-583.

29.  Tsuji Y, Clausen H, Nudelman E, Kaizu T, Hakomori S, Isojima S (1988). Human sperm carbohydrate antigens defined by an anti-sperm human monoclonal antibody derived from an infertile woman bearing anti-sperm antibodies in her serum. J Exp Med 168:343-356.

30.  Dabelsteen E, Clausen H, Reibel J, Holmstrup P (1988). Premalignant and malignant oral lesions are associated with changes in glycosylation patterns of carbohydrates related to ABH blood group antigens. APMIS 96:813-19.

31.  Mygind H, Nielsen B, Moe D, Clausen H, Dabelsteen E, Clausen-Prætoris P (1988). Antikeratin antibodies in routine diagnostic pathology. APMIS 96:1009-1022.

32.  Philipsen EK, Clausen H, Dabelsteen E, Graem N (1988). Blood group related carbohydrate antigens in human fetal pancreas. APMIS 96:1109-1117.

33.  Mandel U, Clausen H, Vedtofte P, Sorensen H, Dabelsteen E (1988). Sequen­tial expression of carbohydrate antigens with precursor-product relation characterizes cellular maturation in stratified squamous epithelium. J Oral Pathol 17:506-511.

34.  Ørntoft T, Wolf H, Clausen H, Dabelsteen E, Hakomori S (1989). Blood group ABH-related antigens in normal and malignant bladder urothelium: possible structural basis for the deletion of type 2 chain ABH antigens in invasive car­cinomas. Int J Cancer 43:774-780.

35.  Kjeldsen T, Hakomori S, Springer GF, Desai P, Harris T, Clausen H (1989). Co-expression of sialosyl-Tn (NeuAca2-6GalNAca1-O-Ser/Thr) and Tn (Gal­NAca1-O-Ser/Thr) blood group antigens on Tn erythrocytes. Vox Sang 57:81-87.

36.  Metoki R, Kakudo K, Tsuji Y, Teng N, Clausen H, Hakomori S (198­9). Dele­tion of histo-blood group A and B antigens, and expression of incom­patible A antigen in ovarian cancer. J Natl Cancer Inst 81:1151-1157.

37.  Nakasaki H, Mitomi T, Noto T, Ogoshi K, Hanaue H, Tanaka Y, Makuuchi H, Clausen H, Hakomori S (1989). Mosaicism in the expression of tumor-associ­ated carbohydrate antigens in human colonic and gastric cancers. Cancer Res 49:3662-3669.

38.  Ørntoft T, Hvid H, Clausen H, Hakomori S, Dabelsteen E (1989). Loss of blood group ABO-related antigen expression in urothelium from patients with chronic cystitis. Lab Invest, 60:305-310.

39.  Ørntoft TF, Holmes EH, Johnson P, Hakomori S, Clausen H (1990). Differen­tial tissue expression of the Lewis blood group antigens: Enzymatic, immuno­his­tologic and immunoche­mical evidence for Lewis a and b antigen expression in Le(a‑b) individuals. Blood 77; 1389-96. 

40.  Inoue H, Hirohashi S, Shimosato Y, Enjoji M, Clausen H, Hakomori S (1989). Establish­ment of an anti‑A human monoclonal antibody from a blood group A lung cancer patient: evidence for the occurrence of autoimmune response to difucosylated type‑2 chain A. Eur J Immunol 19: 2197‑2203. 

41.  Reibel J, Clausen H, Dale BA, Thacher SM (1989). Immunohis­tochemical analysis of stratum corneum components in oral squamous epithelia. Dif­ferentiation 41: 237-44.

42.  Singhal AK, Ørntoft TF, Nudelman E, Nance S, Schibig L, Stroud MR, Clausen H, Hakomori S (1990). Profiles of Lewis x-containing glycopro­teins and glycolipids in sera of patients with adenocarcinoma. Cancer Res, 50:1375-1380.

43.  Hansen J‑ES, Clausen H, Nielsen C, et al. (1990). Inhibition of human im­munodefi­ciency virus (HIV) infection in vitro by anticarbohydrate monoclonal antibodies: Peripheral glycosylation of HIV envelope glycoprotein gp120 may be a target for virus neutralization. J Virol 64: 2833‑2840. 

44.  Holgersson J, Clausen H, Hakomori S, Samuelsson BE, Breimer ME (1990). Blood group A glycolipid antigen expression in kidney, ureter, kidney artery, and kidney vein from a blood group A1Le(a‑b+) human individual. J Biol Chem 265: 20790‑­20798. 

45.  Loridon‑Rosa B, Vielh P, Matsuura H, Clausen H, Cuadrado C, Burtin P (1990). Distribution of oncofetal fibronectin in human mammary tumors: immunofluores­cence study on histological sections. Cancer Research 50: 1608‑1612. 

46.  Mandel U, White T, Karkov J, Hakomori S, Clausen H, Dabelsteen E (1990). Expression of the histo‑blood group ABO gene defined glycosyl­transfera­ses in epithelial tissues. J Oral Pathol Med 19: 251‑256. 

47.  White T, Mandel U, Ørntoft TF, Dabelsteen E, Karkov J, Hakomori S, Clausen H  (1990). Murine monoclonal antibodies directed to the human histo‑blood group A transferase (UDP‑GalNAc: Fuca1‑2Gal­ b1‑3‑N‑Acetylgal­actosaminyl­transferase) and the presence therein of N‑linked histo‑blood group A determi­nant. Biochemistry 29: 2740‑2747. 

48Clausen H, White T, Takio K, Titani K, Stroud M, Holmes E, Karkov J, Thim L, Hakomori S (1990). Isolation to homogeneity and partial characterization of a histo‑blood group A defined Fuca1‑2Gal a1‑3‑N‑acetylgalactosaminyltransferase from human lung tissue. J Biol Chem 265: 1139‑1145. 

49.  Yamamoto F, Marken J, Tsuji T, White T, Clausen H, Hakomori S (1990). Cloning and characterization of DNA complementary to human UDP‑Gal­NAc: Fuca1‑2Gal b1‑3GalNAc transferase (histo‑blood group A transferase) mRNA. J Biol Chem 265: 1146‑1151. 

50.  Yamamoto F, Clausen H, White T, Marken J, Hakomori S (1990). Molecular genetic basis of the histo‑blood group ABO system. Nature 345: 229‑233. 

51.  Arendrup M, Hansen J‑ES, Clausen H, Nielsen C, Mathiesen LR, Nielsen JO (1991). Antibody to histo‑blood group A antigen neutralizes HIV produced by lymphocytes from blood group A donors but not from blood group B or O donors. AIDS 5: 441‑444. 

52.  Ørntoft T, Greenwell P, Clausen H, Watkins WM (1991). Regulation of the on­codevelopmental expression of type 1 chain ABH and Le(b) blood group antigen expression in human colon by a1-2-fucosylation. Gut 32:287-293.

53.  Vangsted AJ, Clausen H, Kjeldsen TB, White T, Sweeney B, Hakomori S, Drivs­holm L, Zeuthen J. Immunochemical detection of a small cell lung cancer-as­sociated gangliosi­de (FucGM1) antigen in serum. Cancer Res. 1991; 51: 2879-84.

54.  Hansen J-ES, Nielsen C, Clausen H, Mathiesen LR, Nielsen JO (1991). Effect of anti-car­bohydrate antibodies on HIV infection in a monocytic cell line (U937). Antiviral Res 16: 233-42.

55.  Mandel U, Petersen OW, Sørensen H, Vedtofte P, Hakomori S, Clausen H, Dabelsteen E (1991). Simple mucin-type carbohydrates in oral stratified squamous and salivary gland epithelia. J Invest Dermatol 97: 713-21

56.  Mandel U, Ørntoft T, Holmes E, Sørensen H, Clausen H, Hakomori S, Dabelsteen E (1991). Lewis blood group antigens in salivary glands and stratified epithelium: Lack of regula­tion of Lewis antigen expression in ductal and buccal mucosal lining epithelia. Vox Sang 61: 205-14.

57.  Hansen J-ES, Nielsen C, Arendrup M, Olofsson S, Mathiesen L, Nielsen JO, Clausen H (1991). Broadly neutralizing antibodies targeted to mucin-type car­bohydrate epitopes of human immunodeficiency virus. J Virol 65:6461; 7. 

58.  Bouchon B, Levery SB, Clausen H, Hakomori S (1992). Production and characterization of a monoclonal antibody (BBH5) directed to ganglioside lactone. Glycoconjugate J 9: 27-38.

59.  Langkilde NC, Wolf H, Clausen H, Kjeldsen T, Ørntoft TF (1992). Nuclear volume and expression of T-antigen, sialosyl-Tn-antigen, and Tn-antigen in car­cinoma of the human bladder. Cancer 69: 219.

60.  Stapleton A, Nudelman E, Clausen H, Hakomori S, Stamm WE (1992). Binding of uropathoge­nic Escherichia coli R45 to glycolipids extracted from vaginal epithelial cells is dependent on histo-blood group secretor status. J Clin Invest 90; 965-72.

61.  Thorn JJ, Levery SB, Salyan MEK, Stroud M, Cedergren B, Nilsson B, Hako­mori S, Clausen H (1992). Structural characterization of X2 glycosphin­golipid, its extended form, and its sialosyl derivatives: Accumulation associated with the rare blood group P phenotype. Biochemistry 31: 6509-17.

62.  David L, Nesland J, Clausen H, Carneiro F, Sobrinho-Simoes M (1992). Simple mucin-type carbohydrate antigens (Tn, sialosyl-Tn and T) in gastric mucosa, carcinomas and metastases. APMIS Suppl. 27, 100: 162-72.

63.  Mandel U, Langkilde NC, Ørntoft TF, Hamilton Therkildsen M, Karkov J, Reibel J, White T, Clausen H, Dabelsteen E (1992). Expression of histo-blood group A/B gene defined glycosyl­transferases in normal and malignant epithelia: correlation with A/B car­bohydrate expression. Int J Cancer 52: 7-12.

64.  Langkilde NC, Wolf H, Clausen H, Ørntoft T (1992). Human urinary bladder carcinoma glycoconjugates expressing T-(Galb(1-3)GalNAca1-O-R) and T-like anti­gens: a com­parative study using peanut agglutinin and poly- and monoclo­nal antibodies. Cancer Res 52: 5030-6.

65.  Mandel U, Hamilton Therkildsen M, Reibel J, Sweeney B, Matsuura H, Hako­mori S, Dabelsteen E, Clausen H (1992). Cancer associated changes in glycosylation of fibronectin. Immunologi­cal localization of oncofetal fibronectin defined by monoclonal antibodies. APMIS 100: 817-26.

66.  Hansen JES, Clausen H, Hu SL, Nielsen JO, Olofsson S (1992). An O-linked carbohydrate neutralization epitope of HIV-1 gp120 is expressed by HIV-1 env gene
recombinant vaccinia virus. Arch Virol 126: 11-20.

67.  Langkilde NC, Wolf H, Clausen H, Ørntoft TF (1992). Localization and identifi­cation of T-(Galb1-3GalNAca1-O-R) and T-like antigens in experimental rat bladder cancer. J Urol 148: 1279-84.

68.  Thurnher M, Clausen H, Fierz W, Lanzavecchia A, Berger, EG (1992). T cell clones with normal or defective O-galactosylation from a patient with perma­nent mixed-field polyagglutina­bility. Eur J Immunol 22: 1835-42.

69.  Pallesen T, Vangsted A, Drivsholm L, Clausen H, Zeuthen J, Wallin H (1992). Serum immu­noassay of a small cell lung cancer associated ganglioside: develop­ment of a sensitive scintillation proximity assay. Glycoconjugate J 9: 331-35.

70.  Jeppe-Jensen D, Clausen H, Leigh IM, Lane EB, Dabelsteen E (1993). Three monoclonal antibodies differentiate human from murine epidermis. Epithelial Cell Biol 2: 100-6.

71.  Ulfvin A, Bäcker AE, Clausen H, Hakomori S, Rydberg L, Samuelsson BE, Breimer ME (1993). Expression of glycolipid blood group antigens in single human kidneys: Change in antigen expression of rejected ABO in­compatible kidney grafts. Kidney Int 44: 1289-97.

72.  David L, Leitao D, Sobrinho-Simoes M, Bennett EP, White T, Mandel U, Dabelsteen E, Clausen H (1993). Biosynthetic basis of incompatible histo-blood group A antigen expression: Anti-A transferase antibodies reactive with gastric cancer tissue of type 0 individuals. Cancer Res 53: 5494-5500.

73.  Nylander K, Larsen JK, Larsen J, Clausen H, Bonding N, Dabelsteen E (1992). The ELAM-1 ligand sialosyl-Lex is present on Langerhans cells isolated from stratified epithelium. Exp Dermatol 1: 236-41.

74.  Thurnher M, Clausen H, Sharon N, Berger EG (1993). Use of O-glycosylation-defec­tive human lymphoid cell lines and flow cytometry to delineate the specificity of Molucella laevis lectin and monoclonal antibody 5F4 for the Tn antigen (GalNAca1-O-Ser/The). Immunol Lett 36: 239-44.

75.  Karsten U, Papsdorf G, Pauly A, Vojtesek B, Moll R, Lane B, Clausen H, Stosiek P, Kasper M (1993). Subtypes of non-transformed human mammary epithelial cells cultured in vitro: histo-blood group antigen H type 2 defines basal cell-derived cells. Differentiation 54: 55-66.

76.  David L, Mandel U, Clausen H, Sobrinho-Simoes M (1993). Immunohistoche­mical expression of oncofetal fibronectin in benign and malignant lesions of the stomach. Eur J Cancer 29A, 2070-1.

77.  Arendrup M, Sönnerborg A, Svennerholm B, Åkerblom L, Nielsen C, Clausen H, Olofsson S, Nielsen JO, Hansen J-ES (1993). Neutralizing antibody respon­se during human immunodefici­en­cy virus type 1 infection: type and group specificity and viral escape. J Gen Virol 74: 855-63.

78.  Therkildsen MH, Mandel U, Christensen M, Clausen H, Dabelsteen E. Simple mucin-type carbohydrate antigens in pleomorphic adenomas. APMIS 101; 242-8: 1993.

79.  Schweizer A, Clausen H, Meer van G, Hauri H-P (1994). Localization of O-glycan initiation, sphingomyelin synthesis, and glucosylceramide synthesis in Vero cells with respect to the endoplasmic reticulum-Golgi intermediate compart­ment. J Biol Chem 269: 4035-41.

80.  Sørensen AMM, Nielsen C, Arendrup M, Clausen H, Nielsen JO, Osinaga E, Roseto A, Hansen J-ES (1994). Neutralization epitopes on HIV pseudotyped with HTLV-I: Conservation of carbohydrate Epitopes. J AIDS 7: 116-23.

81.  Carneiro F, Santos L, David L, Dabelsteen E, Clausen H, Sobrinho-Simoes M (1994). T (Thomsen-Friedenreich) antigen and other simple mucin-type carbohy­drate antigens in precursor lesions of gastric carcinoma. Histopatho­logy 24: 105-13.

82.  Clausen H, Pallesen T, White T, Wandall H, Hansen J-ES. Simple mucin type O-glycans of HIV: enzymatic prediction of glycosylation sites for vaccine construction. In: Complex carbohydrates in drug research. Structural and functional aspects. Alfred Benzon Symposium 36. Bock K, Clausen H, eds. Munksgaard, København 1994.

83.  Meldgaard P, Holmes EH, Bennett EP, Clausen H, Zeuthen J, Wolf H, Ørntoft TF (1994). Blood group ABO-related glycosylation of urothelial cell lines: immunocyto­logical, enzymatic, and genetic characterization. Cancer Res 54: 2440-47.

84.  Reed W, Bryne M, Clausen H, Dabelsteen E, Nesland JM (1994). Simple mucins (T, sialosyl-T, Tn and sialosyl-Tn) are not diagnostic for malignant breast lesions. Anticancer Res 14: 609-616.

85.  Thurnher M, Wagner E, Clausen H, Mechtler K, Rusconi S, Dinter A, Birnstiel ML, Berger EG, Cotten M (1994). Carbohydrate receptor-mediated gene transfer to human T leukaemic cells. Glycobiology 4: 429-35.

86.  Grunnet N, Steffensen R, Bennett EP, Clausen H (1994). Evaluation of histo-blood group ABO genotyping in a Danish population: frequency of a novel O allele defined as O2. Vox Sang 67: 210-15.

87.  Stroud MR, Levery SB, Mårtensson S, Salyan MEK, Clausen H, Hakomori S (1994). Human tumor-associated Lea-Lex hybrid carbohydrate antigen IV3(Galb1-3[Fuca1-4]GlcNAc)III3­FucnLc4 defined by monoclonal antibody 43-9F: Enzymatic synthesis, structural charac­terization, and comparative reactivity with various antibodies. Biochemistry 33: 10672-80.

88.  Mandel U, Gaggero B, Reibel J, Hamilton Therkildsen M, Dabelsteen E, Clausen H (1994). Oncofetal fibronectins in oral carcinomas: Correlation of two different types. APMIS 102: 695-702.

89.  Carsons S, Clausen H, Wolf J (1994). Expression of a developmentally regulated epitope on fibronectins from the synovial fluid of patients with rheumatic disease. J Rheumatol 21: 1888-91.

90.  Bennett EP, Steffensen R, Clausen H, Weghuis DO, van Kessel AG (1995). Genomic cloning of the human histo-blood group ABO locus. Biochem Biophys Res Commun 1995; 206: 318-25.

91.  Hannibal J, Mikkelsen JD, Clausen H, Holst JJ, Wulff BS, Fahrenkrug J. Gene expression of pituitary adenylate cyclase activating polypeptide (PACAP) in the rat hypothalamus. Regul Pept 1995; 55: 133-48.

92.  White T, Bennett EP, Takio K, Sørensen T, Bonding N, Clausen H (1995). Purification and cDNA cloning of a human UDP-N-acetyl-α-D-galactosamine: Polypeptide N-Acetylgalactosaminyltransferase. J Biol Chem 270: 24156-24165.

93.  Sørensen T, White T, Wandall HH, Kristensen AK, Roepstorff P, Clausen H (1995). UDP-N-acetyl-a-D-galactosamine: Polypeptide N-Acetylgalac­tosaminyl­transferase. Identification and separation of two distinct transferase activities. J Biol Chem 270; 24166-24173.

94.  Bennett EP, Hassan H, Clausen H (1996). cDNA cloning and expression of a novel human UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase, GalNAc-T3. J Biol Chem 271; 17006-12.

95.  Hansen J-ES, Jansson B, Gram GJ, Clausen H, Nielsen JO, Olofsson S (1996). Sensitivity of HIV-1 to neutralization by antibodies against O-linked carbohydrate epitopes despite deletion of O-glycosylation signals in the V3 loop. Arch Virol 141: 291-300.

96.  Wiels J, Taga S, Tétaud C, Cedergren B, Nilsson B, Clausen H (1996). Histo-blood group p: biosynthesis of globoseries glycolipids in EBV-transformed B cell lines. Glycoconjugate J 13: 529-35.

97.  Nielsen PA, Mandel U, Therkildsen MH, Clausen H (1996). Differential expression of human high-molecular-weight salivary mucin (MG1) and low-molecular-weight salivary mucin (MG2). J Dent Res 75: 1820-26.

98.  Sönnichsen B, Watson R, Clausen H, Misteli T, Warren G (1996). Sorting by COP-coated vesicles under interphase and mitotic conditions. J Cell Biol 134: 1411-25.

99.  Nielsen PA, Mandel U, Therkildsen MH, Ravn V, David L, Reis CA, Wandall HH, Dabelsteen E, Clausen H (1997). Loss of a novel mucin-like epithelial glycoprotein in oral and cervical squamous cell carcinomas. Cancer Res 57: 634-40.

100.  Reis C, David L, Nielsen PA, Clausen H, Mirgorodskaya K, Roepstorff P, Sobrinho-Simoes M (1997). Immunohistochemical study of MUC5AC expression in human gastric carcinomas using a novel monoclonal antibody. Int J Cancer 74; 112-21.

101.  Norén K, Hansen HH, Clausen H, Norén O, Sjöström H, Vogel LK (1997). Defectively N-glycosylated and non-O-glycosylated aminopeptidase N (CD13) is normally expressed at the cell surface and has full enzymatic activity. Exp Cell Res 231: 112-18.

102.  Nielsen PA, Bennett EP, Wandall HH, Therkildsen MH, Hannibal J, Clausen H (1997). Identification of a major human high molecular weight salivary mucin (MG1) as tracheobron­chial mucin MUC5B. Glycobiology 7; 413-19.

103.  Böhm CM, Mulder MC, Zennadi R, Notter M, Schmitt-Gräff A, Finn OJ, Taylor-Papadimitriou J, Stein H, Clausen H, Riecken EO, Hanski C (1997). Carbohydrate recognition on MUC1-expressing targets enhances cytotoxicity of a T cell subpopulation. Scand J Immunol 46; 27-34.

104.  Wandall HH, Hassan H, Mirgorodskaya K, Kristensen AK, Roepstorff P, Bennett EP, Nielsen PA, Hollingsworth MA, Burchell J, Taylor-Papadimitriou J, Clausen H (1997). Substrate specificities of three members of the human UDP-N-acetyl-a-D-galactosamine: polypeptide N-Acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3. J Biol Chem 272: 23503-14.

105.  Sutherlin ME, Nishimori I, Caffrey T, Bennett EP, Hassan H, Mandel U, Mack D, Iwamura T, Clausen H, Hollingsworth MA (1997). Expression of three UDP-N-acetyl-a-D-galactosamine polypeptide N-acetylgalactosaminyltransferases in adenocarcinoma cell lines. Cancer Res 57: 4744-8.

106.  Almeida R, Amado M, David L, Levery SB, Holmes EH, Merkx G, van Kessel AG, Rygaard E, Hassan H, Bennett EP, Clausen H (1997). A family of human b4-galactosyltransferases: Cloning and expression of two novel UDP-galactose: b-N-acetyl-glucosamine b1,4galactosyltransferases, b4Gal-T2 and b4Gal-T3. J Biol Chem 272: 31979-91.

107.  Röttger S, White J, Wandall HH, Bennett EP, Stark A, Olivo J-C, Whitehouse C, Berger EG, Clausen H, Nilsson T (1997). Differential localization of three human GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus. J Cell Sci 111: 45-60

108.  Bennett EP, Weghuis DO, Merkx G, van Kessel, AG, Eiberg H, Clausen H (1998). Genomic organisation and chromosomal localization of three members of the UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase family. Glycobiology 8: 547-55.

109.  Reis CA, Sørensen T, Mandel U, David L, Mirgorod­skaya K, Roepstorff P, Kihlberg J, Hansen J-ES, Clausen H. (1998). Development and characterization of an antibody directed to an a-N-acetyl-D-galactosamine glycosylated MUC2 peptide. Glycoconjugate J 15: 51-62.

110.  Amado M, Almeida R, Carneiro F, Levery SB, Holmes EH, Nomoto M, Hollingsworth MA, Hassan H, Schwientek T, Nielsen PA, Bennett EP, Clausen H (1998). A family of human b3-galactosyltransferases. Characterization of four members of a UDP-galactose: b-N-acetyl-glycosamine/b-N-acetyl-galactosamine b-1,3-galactosyltransferase family. J Biol Chem 273: 12770-78.

111.  Amado M, Carneiro F, Seixas M, Clausen H, Sobrinho-Simoes M (1998). Dimeric sialyl-Le(x) expression in gastric carcinoma correlates with venous invasion and poor outcome. Gastroenterology 114: 462-70.

112.  Reis CA, Hassan H, Bennett EP, Clausen H (1998). Characterization of a panel of monoclonal antibodies using GalNAc glycosylated peptides and recombinant MUC1. Tumor Biol 19, 127-133.

113.  Klumperman J, Schweizer A, Clausen H, Tang BL, Hong W, Oorschot V, Hauri HP (1998). The recycling Pathway of protein ERGIC-53 and dynamics of the ER-Golgi intermediate compartment. J Cell Sci 111:3411-25

114.  Bennett EP, Hassan H, Mandel U, Mirgorodskaya E, Roepstorff P, Burchell J, Taylor-Papadimitriou J, Hollingsworth MA, Merkx G, van Kessel AG, Eiberg H, Steffensen R, Clausen H (1998). Cloning of a human UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat.. J Biol Chem 273:30472-482.

115.  Schwientek T, Almeida R, Levery SB, Holmes EH, Bennett EP, Clausen H (1998). Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine b1,4-galactosyltransferase family, b4Gal-T4, involved in glycosphingolipid biosynthesis. J Biol Chem 273:29331-340.

116.  Kinarsky L, Nomoto M, Ikematsu Y, Hassan H, Bennett EP, Cerny RL, Clausen H, Hollingsworth MA, Sherman S (1998). Structural analysis of peptide substrates for mucin-type O-glycosylation. Biochemistry 37:12811-7

117.  Sharma P, Dudus L, Nielsen PA, Clausen H, Yankaskas JR, Hollingsworth MA, Engelhardt JF (1998). MUC5B and MUC7 are differentially expressed in mucous and serous cells of submucosal glands in human bronchial airways. Am J Respir Cell Mol Biol 19:30-7

118.  Ujita M, McAuliffe, Schwientek T, Almeida R, Hindsgaul O, Clausen H, Fukuda M (1998). Synthesis of poly-N-acetyllactosamine in core 2 branched O-glycans: The requirement of a novel b-1,4-galactosyltransferase IV and b-1,3-N-acetylglucosaminyltransferase. J Biol Chem 273:34843-849.

119.  Schwientek T, Nomoto M, Levery SB, Merkx G, van Kessel AG, Bennett EP, Hollingsworth MA, Clausen H, (1999). Control of O-Glycan Branch Formation: Molecular cloning of Human cDNA Encoding a Novel b1,6-N-Acetylglucosaminyltransferase Forming Core 2 and Core 4. J Biol Chem 274:4504-12.

120.  Mandel U, Hassan H, Therkildsen MH, Nielsen P, Rygaard J, Jacobsen MH, Juhl BR, Clausen H (1999). Production and characterization of monoclonal antibodies to three human members of the polypeptide GalNAc-transferase family. Glycobiology 9:43-52.

121.  Farmaki T, Ponnambalam S, Prescott AR, Clausen H, Tang B-L, Hong W, Lucocq JM (1999). Dynamics of protein traffic in animal cell mitosis. Pre-COPII arrest of protein traffic is accompanied by retrograde transport of the intermediate compartment protein ERGIC-53/p58 but not the Golgi stack resident GalNAc-transferase. J Cell Sci 112:589-600.

122.  Reis CA, David L, Correa P, Carneiro F, DeBolós C, Garcia E, Mandel U, Clausen H, Sobrinho-Simões M (1999). Intestinal metaplasia of the human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, MUC6) expression. Cancer Res 59:1003-7.

123.  Mirgorodskaya E, Hassan H, Wandall HH, Clausen H, Roepstorff P (1999). Partial vapor phase hydrolysis of peptide bonds: a method for mass spectrometric determination of O-glycosylated sites in glycopeptides. Analyt Biochem 269:54-65.

124.  Ujita M, McAuliffe, Suzuki M, Hindsgaul O, Clausen H, Fukuda MN, Fukuda M (1999). Regulation of I-branched poly-N-acetyllactosamine synthesis: Concerted actions by i-extension enzyme, I-branching enzyme, and b1,4-Galactosyltransferase I. J Biol Chem 274:9296-304.

125.  Hanisch FG, Muller S, Hassan H, Clausen H, Zachara N, Gooley AA, Paulsen H, Alving K, Peter-Katalinic J (1999). Dynamic epigenetic regulation of initial O-glycosylation by UDP-N-acetylgalactosamine:Peptide N-acetylgalactosaminyltransferases. site-specific glycosylation of muc1 repeat peptide influences the substrate qualities at adjacent or distant ser/thr positions. J Biol Chem 274:9946-54

126.  Iida S, Takeuchi H, Hassan H, Clausen H, Irimura T (1999). Incorporation of N-acetylgalactosamine into consecutive threonine residues in MUC2 tandem repeat by recombinant human N-acetyl-D-galactosamine transferase-T1, T2 and T3. FEBS Lett 449:230-4

127.  Bennett EP, Hassan H, Mandel U, Hollingsworth MA, Akisawa N, Ikematsu Y, Merkx G, van Kessel AG, Olufsson S, Clausen H. (1999) Cloning and Characterization of a Close Homologue of Human UDP-N-acetyl-a-D-galactosamine: Polypeptide N-Acetylgalactosaminyltransferase T3, designated GalNAc-T6: Evidence for Genetic but not Functional Redundancy. J Biol Chem 274: 25362-25370.

128.  Almeida R, Levery SB, Mandel U, Kresse H, Schwientek T, Bennett EP, Clausen H (1999). Cloning and Expression of a Proteoglycan UDP-Galactose: b-Xylose b1,4-Galactosyltransferase I: A Seventh Member of the Human b4Galactosyltransferase Gene Family. J Biol Chem 274: 26165-26171.

129.  Bennett, E.P., Hassan, H., Hollingsworth, M.A., and Clausen, H. (1999). A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates.  FEBS lett 460:226-30.

130.  Burchell J, Poulsom R, Hanby A, Whitehouse C, Cooper L, Clausen H, Miles D, Taylor-Papadimitriou J (1999). An alpha2,3 sialyltransferase (ST3Gal I) is elevated in primary breast carcinomas. Glycobiology 9:1307-11

131.  Reis CA, David L, Carvalho F, Mandel U, de Bolos C, Mirgorodskaya E, Clausen H, Sobrinho-Simoes M (2000). Immunohistochemical study of the expression of MUC6 mucin and Co-expression of other secreted mucins (MUC5AC and MUC2) in human gastric carcinomas. J Histochem Cytochem 48:377-88

132.  Kristiansen OP, Pociot F, Bennett EP, Clausen H, Johannesen J, Nerup J, Mandrup-Poulsen T (2000). IDDM7 links to insulin-dependent diabetes mellitus in Danish multiplex families but linkage is not explained by novel polymorphisms in the candidate gene GALNT3. The Danish Study Group of Diabetes in Childhood and The Danish IDDM Epidemiology and Genetics Group. Hum Mutat 15:295-6

133.  Schwientek,T.; Yeh,J.C.; Levery,S.B.; Merkx,G.; van Kessel,A.G.; Keck,B.; Fukuda,M.; Clausen,H. (2000). Control of O-Glycan Branch Formation: Molecular Cloning and Characterization of a Novel Thymus Associated Core 2 b1,6-N-acetylglucosaminyltransferase. J Biol Chem. 275: 11106-11113

134.  Steffensen R, Carlier K, Wiels J, Levery SB, Stroud M, Cedergren B, Sojka BN, Bennett EP, Jersild C, Clausen H (2000). Cloning and Expression of the Histo-Blood Group Pk UDP-Galactose: Galb1-4Glcb1-Cer a1,4-Galactosyltransferase: Molecular Genetic Basis of the p Phenotype. J Biol Chem 275:16723-16729

135.  Bruckner K, Perez L, Clausen H, Cohen S (2000). Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature 406:411-5

136.  Hassan H, Reis CA, Bennett EP, Mirgorodskaya E, Roepstorff P, Hollingsworth MA, Burchell J, Taylor-Papadimitriou J, Clausen H (2000). The lectin domain of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T4 directs its glyco-peptide specificities. J Biol Chem 275:38197-205

137.  Mirgorodskaya E, Hassan H, Clausen H, Roepstorff P. (2000) Mass spectrometric determination of O-glycosylation sites using beta-elimination and partial acid hydrolysis. Anal Chem. 73:1263-9.

138.  Biller M, Mardberg K, Hassan H, Clausen H, Bolmstedt A, Bergstrom T, Olofsson S. (2000) Early steps in O-linked glycosylation and clustered O-linked glycans of herpes simplex virus type 1 glycoprotein C: effects on glycoprotein properties. Glycobiology 10:1259-69

139.  Amado M, Bennett EP, Carneiro F, Clausen H. (2000) Characterization of the histo-blood group O(2) gene and its protein product. Vox Sang 79:219-26.

140.  Dalziel M, Whitehouse C, McFarlane I, Brockhausen I, Gschmeissner S, Schwientek T, Clausen H, Burchell JM, Taylor-Papadimitriou J. (2001) The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1. J Biol Chem 276:11007-15.

141.  George SK, Schwientek T, Holm B, Reis CA, Clausen H, Kihlberg J (2001). Chemoenzymatic Synthesis of Sialylated Glycopeptides Derived from Mucins and T-Cell Stimulating Peptides. J Am Chem Soc 123:11117-11125.

142.  Kato K, Takeuchi H, Kanoh A, Mandel U, Hassan H, Clausen H, Irimura T. (2001). N-acetylgalactosamine incorporation into a peptide containing consecutive threonine residues by UDP-N-acetyl-D-galactosaminide:polypeptide N-acetylgalactosaminyltransferases. Glycobiology 11(10):821-9.

143.  Hanisch FG, Reis CA, Clausen H, Paulsen H. (2001). Evidence for glycosylation-dependent activities of polypeptide N-acetylgalactosaminyltransferases rGalNAc-T2 and -T4 on mucin glycopeptides. Glycobiology 11(9):731-40.

144.  Kato K, Takeuchi H, Miyahara N, Kanoh A, Hassan H, Clausen H, Irimura T. (2001). Distinct orders of GalNAc incorporation into a peptide with consecutive threonines. Biochem Biophys Res Commun 287(1):110-5.

145Vinten J, Voldstedlund M, Clausen H, Christiansen K, Carlsen J, Tranum-Jensen J (2001). A 60-kDa protein abundant in adipocyte caveolae. Cell Tissue Res. 305(1):99-106.  

146.  Haselmann KF, Budnik BA, Olsen JV, Nielsen ML, Reis CA, Clausen H, Johnsen AH, Zubarev RA. (2001). Advantages of external accumulation for electron capture dissociation in Fourier transform mass spectrometry. Anal Chem 73(13):2998-3005.

147Mirgorodskaya E, Hassan H, Clausen H, Roepstorff P. (2001). Mass spectrometric determination of O-glycosylation sites using beta-elimination and partial acid hydrolysis. Anal Chem 73(6):1263-9.

148.  Bulter T, Schumacher T, Namdjou DJ, Gutierrez Gallego R, Clausen H, Elling L. (2001). Chemoenzymatic synthesis of biotinylated nucleotide sugars as substrates for glycosyltransferases. Chembiochem 2:884-94

149.  Schwientek TJ, Bennett EP, Flores C, Thacker J, Hollman M, Reis CA, Behrens J, Mandel U, Keck B, Schafer MA, Hazelmann K, Zubarev R, Roepstorff P, Hollingsworth MA, Clausen H (2002). Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine: Polypeptide N-acetylgalactosaminyltransferases in drosophila, C. elegans and mammals: One subfamily comprised of l(2)35Aa is essential in drosophila. J Biol Chem 277:22623-38

150.  Schwientek T, Keck B, Levery SB, Jensen MA, Pedersen JW, Wandall HH, Stroud M, Cohen SM, Amado M, Clausen H. (2002). The Drosophila gene brainiac encodes a glycosyltransferase putatively involved in glycosphingolipid synthesis. J Biol Chem 277:32421-9

151.  Takeuchi H, Kato K, Denda-Nagai K, Hanisch F, Clausen H, Irimura T (2002). The epitope recognized by the unique anti-MUC1 monoclonal antibody MY.1E12 involves sialylalpha2-3galactosylbeta1-3N-acetylgalactosaminide linked to a distinct threonine residue in the MUC1 tandem repeat. .J Immunol Methods 270:199

152.  Takeuchi H, Kato K, Hassan H, Clausen H, Irimura T (2002). O-GalNAc incorporation into a cluster acceptor site of three consecutive threonines. Eur J Biochem 269:6173-83

153.  Wandall HH, Pedersen JW, Park C, Levery SB, Pizette S, Cohen SM, Schwientek T, Clausen H. (2002) Drosophila egghead encodes a b1,4mannosyltransferase predicted to form the immediate precursor glycosphingolipid substrate for Brainiac. J Biol Chem 278:1411-4.

154.  Marcos NT, Cruz A, Silva F, Almeida R, David L, Mandel U, Clausen H, Von Mensdorff-Pouilly S, Reis CA. (2003). Polypeptide GalNAc-transferases, ST6GalNAc-transferase I, and ST3Gal-transferase I Expression in Gastric Carcinoma Cell Lines. J Histochem Cytochem 51:761-71.

155.  Takeuchi H, Kato K, Hassan H, Clausen H, Irimura T. (2003) O-GalNAc incorporation into a cluster acceptor site of three consecutive threonines. Distinct specificity of GalNAc-transferase isoforms. Eur J Biochem 269:6173-83.

156.  Ragupathi G, Koide F, Sathyan N, Kagan E, Spassova M, Bornmann W, Gregor P, Reis CA, Clausen H, Danishefsky SJ, Livingston PO. (2003) A preclinical study comparing approaches for augmenting the immunogenicity of a heptavalent KLH-conjugate vaccine against epithelial cancers. Cancer Immunol Immunother 52:608-16.

157.  Tetaud C, Falguieres T, Carlier K, Lecluse Y, Garibal J, Coulaud D, Busson P, Steffensen R, Clausen H, Johannes L, Wiels J. (2003) Two distinct Gb3/CD77 signaling pathways leading to apoptosis are triggered by anti-Gb3/CD77 mAb and verotoxin-1. J Biol Chem. 278:45200-8

158.  Kinarsky L, Suryanarayanan G, Prakash O, Paulsen H, Clausen H, Hanisch FG, Hollingsworth MA, Sherman S. (2003) Conformational studies on the MUC1 tandem repeat glycopeptides: implication for the enzymatic O-glycosylation of the mucin protein core. Glycobiology 13:929-939.

159.  Hoffmeister KM, Josefsson EC, Isaac NA, Clausen H, Hartwig JH, Stossel TP. (2003). Glycosylation restores survival of chilled blood platelets. Science 301(5639):1531-4.

160.  Mardberg K, Nystrom K, Tarp MA, Trybala E, Clausen H, Bergstrom T, Olofsson S. (2004). Basic amino acids as modulators of an O-linked glycosylation signal of the herpes simplex virus type 1 glycoprotein gC: functional roles in viral infectivity. Glycobiology 14:571-81.

161.  Mungul A, Cooper L, Brockhausen I, Ryder K, Mandel U, Clausen H, Rughetti A, Miles DW, Taylor-Papadimitriou J, Burchell JM. (2004) Sialylated core 1 based O-linked glycans enhance the growth rate of mammary carcinoma cells in MUC1 transgenic mice.
Int J Oncol. 25:937-43.

162.  Marcos NT, Pinho S, Grandela C, Cruz A, Samyn-Petit B, Harduin-Lepers A, Almeida R, Silva F, Morais V, Costa J, Kihlberg J, Clausen H, Reis CA. (2004). Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen. Cancer Res. 64:7050-7.

163.  Kagan E, Ragupathi G, Yi SS, Reis CA, Gildersleeve J, Kahne D, Clausen H, Danishefsky SJ, Livingston PO. (2005) Comparison of antigen constructs and carrier molecules for augmenting the immunogenicity of the monosaccharide epithelial cancer antigen Tn. Cancer Immunol Immunother. 54(5):424-30

164.  Wandall HH, Pizette S, Pedersen JW, Eichert H, Levery SB, Mandel U, Cohen SM, Clausen H. (2005) Egghead and brainiac are essential for glycosphingolipid biosynthesis in vivo. J Biol Chem 280:4858-63.

165.  Slovin SF, Ragupathi G, Fernandez C, Jefferson MP, Diani M, Wilton AS, Powell S, Spassova M, Reis C, Clausen H, Danishefsky S, Livingston P, Scher HI. (2005). A bivalent conjugate vaccine in the treatment of biochemically relapsed prostate cancer: a study of glycosylated MUC-2-KLH and Globo H-KLH conjugate vaccines given with the new semi-synthetic saponin immunological adjuvant GPI-0100 OR QS-21. Vaccine 23(24):3114-22.

166.  Rughetti A, Pellicciotta I, Biffoni M, Backstrom M, Link T, Bennet EP, Clausen H, Noll T, Hansson GC, Burchell JM, Frati L, Taylor-Papadimitriou J, Nuti M. Recombinant tumor-associated MUC1 glycoprotein impairs the differentiation and function of dendritic cells (2005) J Immunol 174:7764-72.

167.  Fuller MD, Schwientek T, Wandall HH, Pedersen JW, Clausen H, Levery SB. (2005) Structure elucidation of neutral di-, tri-, and tetraglycosylceramides from High FiveTM cells. Identification of a novel (non-arthro-series) glycosphingolipid pathway. Glycobiology 15:1286-301

168.  Irazoqui FJ, Vozari-Hampe MM, Lardone RD, Villarreal MA, Sendra VG, Montich GG, Trindade VM, Clausen H, Nores GA. (2005) Fine carbohydrate recognition of Euphorbia milii lectin. Biochem Biophys Res Commun 336(1):14-21

169.  Sorensen AL, Reis CA, Tarp MA, Mandel U, Ramachandran K, Sankaranarayanan V, Schwientek T, Graham R, Taylor-Papadimitriou J, Hollingsworth MA, Burchell J, Clausen H. (2006) Chemoenzymatically synthesized multimeric Tn/STn MUC1 glycopeptides elicit cancer specific anti-MUC1 antibody responses and override tolerance. Glycobiology 16(2):96-107.

170.  Sewell R, Backstrom M, Dalziel M, Gschmeissner S, Karlsson H, Noll T, Gatgens J, Clausen H, Hansson GC, Burchell J, Taylor-Papadimitriou J (2006) The ST6GalNAc-I sialyltransferase localises throughout the Golgi and is responsible for the synthesis of the tumour associated sialyl Tn O-glycan in human breast cancer. J Biol Chem 281(6):3586-94

171van Leeuwen EB, Cloosen S, Senden-Gijsbers BL, Agervig Tarp M, Mandel U, Clausen H, Havenga MJ, Duffour MT, Garcia-Vallejo JJ, Germeraad WT, Bos GM. (2006) Expression of aberrantly glycosylated tumor mucin-1 on human DC after transduction with a fiber-modified adenoviral vector. Cytotherapy 8(1):24-35

172Kato K, Jeanneau C, Tarp MA, Benet-Pages A, Lorenz-Depiereux B, Bennett EP, Mandel U, Strom TM, Clausen H. (2006) Polypeptide GaINAc-transferase T3 and familial tumoral calcinosis: Secretion of FGF23 requires O-glycosylation. J Biol Chem 281:18370-7

173.  DeFrees S, Wang Z, Xing K, Scott AE, Wang J, Zopf D, Gouty DL, Sjoberg ER, Panneerselvam K, Brinkman-Van der Linden ECM, Bayer RJ, Tarp MA, Clausen H. (2006) GlycoPegylation of recombinant therapeutic proteins produced in E. coli. Glycobiology 16: 833-843

174.  Cloosen S, Gratama J, van Leeuwen EB, Senden-Gijsbers BL, Oving EB, von Mensdorff-Pouilly S, Tarp MA, Mandel U, Clausen H, Germeraad WT, Bos GM (2006) Cancer specific Mucin-1 glycoforms are expressed on multiple myeloma. Br J Haematol. 135:513-6. 

175.  Tarp MA, Sørensen AL, Mandel U, Paulsen H, Burchell J, Taylor-Papadimitriou, Clausen H (2007). Identification of a Novel Cancer Specific Immunodominant Glycopeptide Epitope in the MUC1 Tandem Repeat. Glycobiology, 17:197-209

176.  Geshi N, Egelund A, Petersen BL, Motawia MS, Damager I, Faik A, Olsen CE, Ishii T, Clausen H, Ulvskov P (2006). Biosynthesis of pectic rhamnogalacturonan II: Molecular coloning and characterization of Golgi-localized a1,3-xylosyltransferases encoded by the RGXT1 and RGXT2 genes of Arabidopsis thaliana. Plant Cell 18:2593-607

177.  Jinek M, Chen Y, Clausen H, Cohen SM, Conti E (2006) Structure of the Notch-modifying glycosyltransferase Fringe. Nature Struc Mol Biol 13:945-6.

178.  Wandall HH, Irazoqui F, Tarp MA, Bennett EP, Mandel U, Takeuchi H, Kato K, Irimura T, Suryanarayanan G, Hollingsworth MA, Clausen H (2007). The lectin domains of polypeptide GalNAc-transferases exhibit carbohydrate binding specificity for GalNAc: Lectin binding to GalNAc-glycopeptide substrates is required for high density GalNAc-O-glycosylation. Glycobiology 17:374-87.

179.  Brooks SA, Carter TM, Bennett EP, Clausen H, Mandel U (2007) Immunolocalisation of members of the polypeptide N-acetylgalactosaminyl transferase (ppGalNAc-T) family is consistent with biologically relevant altered cell surface glycosylation in breast cancer. Acta Histochem 2007 Apr 18

180.  Liu QP, Sulzenbacher G, Yuan H, Bennett EP, Pietz G, Saunders K, Spence J, Nudelman E, Levery SB, White T, Neuve JM, Lane WS, Bourne Y, Olsson ML, Henrissat H, Clausen H (2007). Universal red cells made possible by novel families of bacterial glycosidases. Nature Biotech 25:454-64.

181.  Chen Y, Pedersen, JW, Wandall HH, Levery SB, Pizette S, Clausen H, Cohen S (2007) Glycosphingolipids with extended sugar chains have specialized functions in development and behavior of Drosophila. Dev Biol 306:736-49.

182.  Norberg P, Olofsson S, Tarp MA, Clausen H, Bergstrom T, Liljeqvist JA (2007). Glycoprotein I of herpes simplex virus type 1 contains a unique polymorphic tandem-repeated mucin region.
J Gen Virol 88:1683-8.

183.  Slovin SF, Ragupathi G, Fernandez C, Diani M, Jefferson MP, Wilton A, Kelly WK, Morris M, Solit D, Clausen H, Livingston P, Scher HI (2007). A polyvalent vaccine for high-risk prostate patients: "are more antigens better?". Cancer Immunol Immunother, Jul 10;

184.  Sabbatini PJ, Ragupathi G, Hood C, Aghajanian CA, Juretzka M, Iasonos A, Hensley ML, Spassova MK, Ouerfelli O, Spriggs DR, Tew WP, Konner J, Clausen H, Abu Rustum N, Dansihefsky SJ, Livingston PO (2007). Pilot study of a heptavalent vaccine-keyhole limpet hemocyanin conjugate plus QS21 in patients with epithelial ovarian, fallopian tube, or peritoneal cancer. Clin Cancer Res 13:4170-7.

185.  Rajpert-De Meyts E, Poll SN, Goukasian I, Jeanneau C, Herlihy AS, Bennett EP, Skakkebaek NE, Clausen H, Giwercman A, Mandel U (2007). Changes in the profile of simple mucin-type O-glycans and polypeptide GalNAc-transferases in human testis and testicular neoplasms are associated with germ cell maturation and tumour differentiation. Virchows Arch, Aug.

186.  Alliende C, Kwon YJ, Brito M, Molina C, Aguilera S, Pérez P, Leyton L, Quest AF, Mandel U, Veerman E, Espinosa M, Clausen H, Leyton C, Romo R, Gonzalez MJ. (2007). Reduced sulfation of MUC5B is linked to xerostomia in Sjogren's Syndrome patients. Ann Rheum Dis. Nov 12

187.  Napoletano C, Rughetti A, Agervig Tarp MP, Coleman J, Bennett EP, Picco G, Sale P, Denda-Nagai K, Irimura T, Mandel U, Clausen H, Frati L, Taylor-Papadimitriou J, Burchell J, Nuti M. (2007). Tumor-Associated Tn-MUC1 Glycoform Is Internalized through the Macrophage Galactose-Type C-Type Lectin and Delivered to the HLA Class I and II Compartments in Dendritic Cells. Cancer Res 67:8358-67.

188.  Wandall HH, Hoffmeister KM, Sorensen AL, Rumjantseva V, Clausen H, Hartwig JH, Slichter SJ. (2007) Galactosylation does not prevent the rapid clearance of long-term 4ºC stored platelets. Blood 111:3249-56.

189.  Liu QP, Yuan H, Bennett EP, Levery SB, Nudelman E, Spence J, Pietz G, Saunders K, White T, Olsson ML, Henrissat B, Sulzenbacher G, Clausen H (2008). Identification of a GH110 subfamily of a1,3-galactosidases: Novel enzymes for removal of the a3Gal xenotransplantation antigen. J Biol Chem 283:8545-54.

190.  Kato K, Takeuchi H, Ohki T, Waki M, Usami K, Hassan H, Clausen H, Irimura T (2008). A lectin recognizes differential arrangements of O-glycans on mucin repeats. Biochem Biophys Res Commun 11;371:698-701.

Reviews and books

2.1  Dabelsteen E, Clausen H (1987).  Tumor‑associated carbohydrate antigens.  J Oral Pathol 16:196-198.

2.2  Clausen H, Hakomori S, Dabelsteen E (1987).  Differentiation antigens in normal epithelia. In: Mackenzie IC, Squier CA, Dabelsteen E, eds. Oral muco­sal diseases: Biology, etiology and therapy (Proc 2d Dows Symp, Iowa.

2.3  Hakomori S, Clausen H, Levery SB (1987).  A new series of blood group A and H antigens expressed in human erythrocytes and the incompatible A antigens expressed in tumors of blood group O and B individuals.  Biochem Soc Trans 15:593-596.

2.4  Clausen H, Levery SB, Dabelsteen E, Hakomori S (1987). A new series of blood group A associated structures:  Genetic regulation and tissue dis­tribution.  Transplant Proc 49:4408-4412.

2.5  Dabelsteen E, Mandel U, Clausen H (1988). Blood group antigens as differen­tia­tion and tumor-associated markers in oral epithelium. Proc Finn Dent Soc 84:19-29.

2.6  Clausen H, Hakomori S (1989). ABH and related histo-blood group antigens: Chemistry and distribution. Vox Sang 56:1-20.

2.7  Dabelsteen, E., Reibel, J. and Clausen, H (1990). Cell surface carbohydrates in differen­tiation and malignant development of oral epithelium. In: Risks markers, edited by Johnson, N.W. Cambridge: Cambridge University Press, p. 203‑217.

2.8  Dabelsteen E, Mandel U, Clausen H (1991). Cell surface carbohydrates are markers of differentia­tion in human oral epithelium. CRC Crit Rev Oral Biol Med 2: 493-507.

2.9  Dabelsteen E, Clausen H, Mandel U (1991). Aberrant glycosylation in oral malignant and premalignant lesions. J Oral Pathol Med 20: 361-8.

2.10  Dabelsteen E, Clausen H (1992). Molecular biology in oral research. Scand J Dent Res 100: 3-8.

2.11  Dabelsteen E, Clausen H, Mandel U (1992). Carbohydrate changes in squamous cell carcinomas. APMIS Suppl. 27, 100: 130-8.

2.12  Clausen H, Bennett EP, Dabelsteen E (1992). Carbohydrates of the cell surface: Molecular aspects of glycosyltransferases and their genes. APMIS Suppl. 27, 100: 9-17.

2.13  Bock K, Clausen H, eds. (1994). Complex carbohydrates in drug research.­Struc­tural and functional aspects. Alfred Benzon Symposium 36. Munks­gaard, Køben­havn.

2.14  Hansen J-ES, Hofmann B, Sørensen T, Clausen H (1994). Role of carbohydrate on HIV and possibilities for anti-viral intervention. In: Complex carbohydrates in drug research.­Struc­tural and functional aspects. Bock K, Clausen H, eds. Alfred Benzon Symposium 36. Munks­gaard, Køben­havn.

2.15  Clausen H, Bennett EP, Grunnet N. (1994). Molecular genetics of ABO histo-blood groups. TBC 2: 79-89.

2.16  Hansen JE, Lund O, Rapacki K, Clausen H, Mosekilde E, Nielsen JO, Hansen J-E. Glycosylation and protein conformation. In: Protein structure by distance analysis. H. Bohr, S. Brunak eds. IOS Press, Amsterdam 1994, 247-254.

2.17  Carneiro F, Amado M, David L, Clausen H (1994). Glycosylation features of gastric carcinoma initiation and progression. A review with emphasis on simple mucin-type carbohydrates and histo-blood group antigens of the Lewis system. Eur J Cancer Prev 2: 39-46.

2.18  Clausen H, Bennett EP (1996). A family of UDP-GalNAc: Polypeptide N-Acetylgalactosaminyltransferases control the initiation of mucin-type O-linked glycosylation. Glycobiology 6: 635-46.

2.19  Amado M, Almeida R, Schwientek T, and Clausen H (1999). Identification and Characterization of Large Galactosyltransferase Gene Families: Galactosyltransferases for all functions. Biochem Biophys Acta 1473;35-53.

2.20  Hassan H, Bennett EP, Mandel U, Hollingsworth MA, and Clausen H (2000). Control of Mucin-Type O-Glycosylation: O-Glycan Occupancy is Directed by Substrate Specificities of Polypeptide GalNAc-Transferases. (Eds. Ernst, Hart, and Sinay). Wiley-VCH chapter “Carbohydrates in Chemistry and Biology – a Comprehension Handbook”, 273-292.

2.21  Olsson ML, Hill CA, de la Vega H, Liu QP, Stroud MR, Valdinocci J, Moon S, Clausen H, Kruskall MS. (2004). Universal red blood cells--enzymatic conversion of blood group A and B antigens. Transfus Clin Biol. 11(1):33-9.

2.22  Olsson ML, Clausen H (2008) Modifying the red cell surface: towards an ABO-universal blood supply. Br J Haematol 140:3-12.

2.23  Tarp MA, Clausen H. (2008). Mucin-type O-glycosylation and its potential use in drug and vaccine development. Biochim Biophys Acta 1780:546-63. 


-  29 US patents issued listed, many of which have international filings and issuances.
-  US and PCT applications in processing (approx. 10) not listed.  

USP 7,381,554 

UDP-N-acetylglucosamine: galactoseβ1,3-N-acetylgalactosaminea-R/N-acetylglucosamineβ1,3-N-acetylgalactosamine-a-R (GlcNAc to GalNAc) β1,6-N-acetylglucosaminyltransferase, C2/4GnT 

USP 7,374,919 

UDP-galactose: β-N-acetyl-glucosamine β-1,4-galactosyltransferase, β4Gal-T2 

USP 7,338,933 

O-linked glycosylation of peptides 

USP 7,338,932 

Methods of modulating functions of polypeptide GalNAc-transferases and of screening test substances to find agents herefor, pharmaceutical compositions comprising such agents and the use of such agents for preparing medicaments 

USP 7,332,279 

UDP-galactose: β-N-acetyl-glucosamine β1,3 galactosyltransferases, β3Gal-T5 

USP 7,241,282 

Compositions and methods for prolonging survival of platelets 

USP 7,115,404 

UDP-galactose: β-D-galactose-R 4-a-D-galactosyltransferase, a4Gal-T1 

USP 7,097,994 

UDP-N-acetylglucosamine:galactose-β1,3-N-acetylgalactosamine-a-R/ (GlcNAc to GaINAc) β1-6 N-acetylglucosaminyltransferase, C2GnT3