publications – University of Copenhagen

Ole William Petersen


papers listed in PubMed 

publications 2000-2008
and selected publications

  • Kenny PA, Lee GY, Myers CA, Neve RM, Semeiks JR, Spellman PT, Lorenz K, Lee EH, Barcellos-Hoff MH, Petersen OW, Gray JW, Bissell MJ.
    The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol. 2007 Jun;1(1):84-96
  • Rizki A, Weaver VM, Lee SY, Rozenberg GI, Chin K, Myers CA, Bascom JL, Mott JD, Semeiks JR, Grate LR, Mian IS, Borowsky AD, Jensen RA, Idowu MO, Chen F, Chen DJ, Petersen OW, Gray JW, Bissell MJ.
    A human breast cell model of preinvasive to invasive transition. Cancer Res. 2008 Mar 1;68(5):1378-87.
  • Petersen OW, Celis JE  
    [Pathogenesis of breast cancer] Ugeskr Laeger. 2007 Sep 3;169(36):2968-72. Review. Danish.
  • LaBarge MA, Petersen OW, Bissell MJ.
    Of microenvironments and mammary stem cells. Stem Cell Rev. 2007 Jun;3(2):137-46. Review. 
  • Villadsen R, Fridriksdottir AJ, Rønnov-Jessen L, Gudjonsson T, Rank F, LaBarge MA, Bissell MJ, Petersen OW.
    Evidence for a stem cell hierarchy in the adult human breast.J Cell Biol. 2007 Apr 9;177(1):87-101.
  • Sigurdsson V, Fridriksdottir AJ, Kjartansson J, Jonasson JG, Steinarsdottir M, Petersen OW, Ogmundsdottir HM, Gudjonsson T
    Human breast microvascular endothelial cells retain phenotypic traits in long-term finite life span culture. In Vitro Cell Dev Biol Anim. 2006 Nov-Dec;42(10):332-40. 
  • Gudjonsson T, Adriance MC, Sternlicht MD, Petersen OW, Bissell MJ.
    Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia. J Mammary Gland Biol Neoplasia. 2005 Jul;10(3):261-72. Review.
  • Thomsen AR, Almstrup K, Nielsen JE, Sørensen IK, Petersen OW, Leffers H, Breinholt VM
    Estrogenic effect of soy isoflavones on mammary gland morphogenesis and gene expression profile.Toxicol Sci. 2006 Oct;93(2):357-68.  
  • Stein T, Price KN, Morris JS, Heath VJ, Ferrier RK, Bell AK, Pringle MA, Villadsen R, Petersen OW, Sauter G, Bryson G, Mallon EA, Gusterson BA.
    Annexin A8 is up-regulated during mouse mammary gland involution and predicts poor survival in breast cancer. Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6872-9. 
  • Adriance MC, Inman JL, Petersen OW, Bissell MJ.
    Myoepithelial cells: good fences make good neighbours. Breast Cancer Res. 2005;7(5):190-7.
  • Fridriksdottir AJ, Villadsen R, Gudjonsson T, Petersen OW.
    Maintenance of cell type diversification in the human breast. J Mammary Gland Biol Neoplasia. 2005 Jan;10(1):61-74. Review.
  • Kaminker P, Plachot C, Kim SH, Chung P, Crippen D, Petersen OW, Bissell MJ, Campisi J, Lelièvre SA
    Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2. J Cell Sci. 2005 Mar 15;118(Pt 6):1321-30. Epub 2005 Mar 1.
  • Gudjonsson, T. R. Villadsen, L. Rønnov-Jessen, and O.W. Petersen. Immortalization protocols used in cell culture models of human breast morphogenesis. Cell. Mol. Life Sci. 61:2523-2534 (2004).
  • Nielsen, H.L., T. Gudjonsson, R. Villadsen, L. Rønnov-Jessen, and O.W. Petersen. Collagen gel contraction serves to rapidly distinguish epithelial- and mesenchymal-derived cells irrespective of alpha-smooth muscle actin expression. In Vitro Cell. Dev. Biol. 39:297-303 (2003).
  • Petersen, O.W., T. Gudjonsson, R. Villadsen, M.J. Bissell, and L. Rønnov-Jessen. Epithelial cell lines as models of normal breast morphogenesis and neoplasia. Cell Proliferation. 36 Suppl 1:33-44. (2003).
  • Gudjonsson, T., L. Rønnov-Jessen, R. Villadsen, M.J Bissell, and O.W. Petersen. To create the correct microenvironment: Three-dimensional collagen culture assays for human breast epithelial morphogenesis and neoplasia. Methods. 30:247-55 (2003).
  • Johansson, O.T., S. Staff, J. Vallon-Christensen, S. Kytola, T. Gudjonsson, K. Rennstam, I.A. Hedenfalk, A. Adeyinka, E. Kjellén, J. Wennerberg, B. Baldetorp. O.W. Petersen, H. Olsson, S. Oredsson, J. Isola, and Å. Borg. Characterization of a novel breast carcinoma xenograft and cell line derived from a BRCA1 germ-line mutation carrier. Lab. Invest. 83:387-96 (2003).
  • Petersen, O.W., H.L. Nielsen, T. Gudjonsson, R. Villadsen, F. Rank, E. Niebuhr, M.J. Bissell, and L. Rønnov-Jessen. Human breast tumor epithelial cells can generate their own stromal myofibroblasts. Am. J. Pathol. 162:391-402 (2003).
  • Bissell, M. J., D.C. Radisky, A. Rizki, V.M. Weaver, and O.W. Petersen. The organizing principle: Microenvironmental influences in the normal and malignant breast. Differentiation. 70:537-46 (2002).
  • Wang, F. R.K. Hansen, D. Radisky, T. Yoneda, M.H. Barchellos-Hoff, O.W. Petersen, E.A. Turley, and M.J. Bissell. Combined alteration of intracellular signalling pathways in a three dimensional context leads to phenotypic reversion or cell death of human breast cancer cells. J. Natl. Cancer Inst. 94:1494-1503 (2002).
  • Rønnov-Jessen, L. R. Villadsen, J.C. Edwards, and O.W. Petersen. Differential expression of a chloride intracellular channel gene, CLIC4, in TGF-beta 1-mediated conversion of fibroblasts to myofibroblasts. Am. J. Pathol. 161:471-480 (2002).
  • Nielsen, H.L., L. Rønnov-Jessen, R. Villadsen, and O.W. Petersen. Identification of EPSTI1, a novel gene induced by epithelial stromal interaction in human breast cancer. Genomics. 79:703-710 (2002).
  • Gudjonsson, T., R. Villadsen, H.L. Nielsen, L. Rønnov-Jessen, M.J. Bissell, and O.W. Petersen. Isolation, immortalization and characterization of a keratin 19-positive suprabasal human breast cell line with stem cell properties: a possible precursor for breast cancer. Genes and Development. 16:693-706 (2002).
  • Gudjonsson, T. L. Rønnov-Jessen, R. Villadsen, M.J. Bissell, and O.W. Petersen. Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. J. Cell Sci. 115:39-50 (2002).
  • Petersen, O.W. H.L. Nielsen, T. Gudjonsson, R. Villadsen, L. Rønnov-Jessen, and M.J. Bissell. The plasticity of human breast carcinoma cells is more than epithelial to mesenchymal conversion. Breast Cancer Res. 3:213-217 (2001).
  • Chen H.-M. K.L. Schmeichel, I.S. Mian, O.W. Petersen, and M.J. Bissell. AZ-1: a candidate breast tumor suppressor with a c-terminal coiled-coil domain. Mol Biol. Cell. 11:1357-1367 (2000).

selected papers before 2000:

  1. Pechoux, C.P., T. Gudjonsson, L. Rønnov-Jessen, M.J. Bissell, and O.W. Petersen. Human mammary luminal epithelial cells contain progenitors to myoepithelial cells. Developmental Biology. 206:88-99 (1999).
  2. Leliévre, S.A., V.M. Weaver, J.A. Nickerson, C.A. Larabell, A. Bhaumik, O.W. Petersen, and >M.J. Bissell. Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus. Proc. Natl. Acad. Sci. (USA). 95:14711-14716 (1998).
  3. Wang, F., V.M. Weaver, O.W. Petersen, C.A. Larabell, S. Deddar, P. Priand, R. Lupu, and >M.J. Bissell. Beta-1-integrin and EGF-R pathways are cross modulated in three dimension and not in monolayer culture: a new perspective in epithelial biology. Proc. Natl. Acad. Sci (USA). 95:14821-14826 (1998).
  4. Petersen, O.W., L. Rønnov-Jessen, V.M. Weaver, and M.J. Bissell. Differentiation and cancer in the mammary gland: shedding new light on an old dichotomy. Adv. Cancer Res. 75:135-161 (1998).
  5. Weaver, V.M., O.W. Petersen, F. Wang, C.A Larabell, P. Briand, C. Damsky, and M.J. Bissell. Reversion of the malignant phenotype of human breast cells in 3-dimensional culture and in vivo using integrin blocking antibodies. J. Cell Biol. 137:231-245 (1997).
  6. Rønnov-Jessen, L., and O.W. Petersen. A function for filamentous a-smooth muscle actin: Retardation of motility in human breast fibroblasts. J. Cell Biol. 134:67-80 (1996).
  7. Rønnov-Jessen, L., O.W. Petersen, and M.J. Bissell. Cellular changes involved in conversion of normal to malignant breast: The importance of the stromal reaction. Physiological Reviews. 76:69-125 (1996).
  8. Briand, P., K.V. Nielsen, M.W. Madsen, and O.W. Petersen. Trisomy 7p and malignant transformation of human breast epithelial cells by EGF withdrawal. Cancer Res. 56:2039-2044 (1996).
  9. Rønnov-Jessen, L., O.W. Petersen, V. Koteliansky, and M.J. Bissell. The origin of the myofibroblast in breast cancer: Recapitulation of tumor environment in culture unravel heterogeneity and implicates converted fibroblasts and recruited smooth muscle cells. J. Clin. Invest. 95:859-873 (1995).
  10. Howlett, A.R., O.W. Petersen, P.S. Steeg, and M.J. Bissell. A novel function for nm23: overexpression in human breast carcinoma cells leads to the formation of basement membrane and growth arrest. J. Natl. Cancer Inst. 86:1838-1844 (1994).
  11. Petersen, O.W., L. Rønnov-Jessen, A.R. Howlett, and M.J. Bissell. Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc. Natl. Acad. Sci. (USA) 89: 9064-9068 (1992).
  12. Petersen, O.W., B. van Deurs, K. Vang Nielsen, M.W. Madsen, I. Laursen, I. Balslev and P. Briand: Differential tumorigenicity of two autologous human breast carcinoma cell lines newly established in serum-free medium. Cancer Res. 50:1257-1270 (1990)
  13. Petersen, O.W., and B. van Deurs: Growth factor control of myoepithelial-cell differentiation in cultures of human mammary gland. Differentiation, 39:197-215 (1988).
  14. Petersen, O.W., P.E. Høyer and B. van Deurs: Frequency and distribution of estrogen receptor positive cells in normal non-lactating human breast tissue. Cancer Res. 47:5748-5751 (1987).
  15. Petersen, O.W., and B. van Deurs: Preservation of defined phenotypic traits in short-term cultured human breast carcinoma derived epithelial cells. Cancer Res. 47:856-866 (1987).
  16. Petersen, O.W., and B. van Deurs: Characterization of epithelial membrane antigen expression in human mammary epithelium by ultrastructural immunoperoxidase cytochemistry. J. Histochem. Cytochem. 34:801-809 (1986).
  17. Petersen, O.W., and B. van Deurs: Demonstration of human breast carcinoma cells in cryosections and primary monolayer cultures of surgical biopsies by neotetrazolium reductase cytochemistry. Cancer Res. 46:2013-2020 (1986).

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