Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1

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Standard

Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1. / Rudjord-Levann, Asha M.; Ye, Zilu; Hafkenscheid, Lise; Horn, Sabrina; Wiegertjes, Renske; Nielsen, Mathias A.I.; Song, Ming; Mathiesen, Caroline B.K.; Stoop, Jesse; Stowell, Sean; Straten, Per Thor; Leffler, Hakon; Vakhrushev, Sergey Y.; Dabelsteen, Sally; Olsen, Jesper V.; Wandall, Hans H.

I: iScience, Bind 26, Nr. 7, 106984, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Rudjord-Levann, AM, Ye, Z, Hafkenscheid, L, Horn, S, Wiegertjes, R, Nielsen, MAI, Song, M, Mathiesen, CBK, Stoop, J, Stowell, S, Straten, PT, Leffler, H, Vakhrushev, SY, Dabelsteen, S, Olsen, JV & Wandall, HH 2023, 'Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1', iScience, bind 26, nr. 7, 106984. https://doi.org/10.1016/j.isci.2023.106984

APA

Rudjord-Levann, A. M., Ye, Z., Hafkenscheid, L., Horn, S., Wiegertjes, R., Nielsen, M. A. I., Song, M., Mathiesen, C. B. K., Stoop, J., Stowell, S., Straten, P. T., Leffler, H., Vakhrushev, S. Y., Dabelsteen, S., Olsen, J. V., & Wandall, H. H. (2023). Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1. iScience, 26(7), [106984]. https://doi.org/10.1016/j.isci.2023.106984

Vancouver

Rudjord-Levann AM, Ye Z, Hafkenscheid L, Horn S, Wiegertjes R, Nielsen MAI o.a. Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1. iScience. 2023;26(7). 106984. https://doi.org/10.1016/j.isci.2023.106984

Author

Rudjord-Levann, Asha M. ; Ye, Zilu ; Hafkenscheid, Lise ; Horn, Sabrina ; Wiegertjes, Renske ; Nielsen, Mathias A.I. ; Song, Ming ; Mathiesen, Caroline B.K. ; Stoop, Jesse ; Stowell, Sean ; Straten, Per Thor ; Leffler, Hakon ; Vakhrushev, Sergey Y. ; Dabelsteen, Sally ; Olsen, Jesper V. ; Wandall, Hans H. / Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1. I: iScience. 2023 ; Bind 26, Nr. 7.

Bibtex

@article{748fa7c0e4984bfa83fb6e065a7d0475,
title = "Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1",
abstract = "Galectins are a group of carbohydrate-binding proteins with a presumed immunomodulatory role and an elusive function on antigen-presenting cells. Here we analyzed the expression of galectin-1 and found upregulation of galectin-1 in the extracellular matrix across multiple tumors. Performing an in-depth and dynamic proteomic and phosphoproteomic analysis of human macrophages stimulated with galectin-1, we show that galectin-1 induces a tumor-associated macrophage phenotype with increased expression of key immune checkpoint protein programmed cell death 1 ligand 1 (PD-L1/CD274) and immunomodulator indoleamine 2,3-dioxygenase-1 (IDO1). Galectin-1 induced IDO1 and its active metabolite kynurenine in a dose-dependent manner through JAK/STAT signaling. In a 3D organotypic tissue model system equipped with genetically engineered tumorigenic epithelial cells, we analyzed the cellular source of galectin-1 in the extracellular matrix and found that galectin-1 is derived from epithelial and stromal cells. Our results highlight the potential of targeting galectin-1 in immunotherapeutic treatment of human cancers.",
keywords = "Cancer, Immunology",
author = "Rudjord-Levann, {Asha M.} and Zilu Ye and Lise Hafkenscheid and Sabrina Horn and Renske Wiegertjes and Nielsen, {Mathias A.I.} and Ming Song and Mathiesen, {Caroline B.K.} and Jesse Stoop and Sean Stowell and Straten, {Per Thor} and Hakon Leffler and Vakhrushev, {Sergey Y.} and Sally Dabelsteen and Olsen, {Jesper V.} and Wandall, {Hans H.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
doi = "10.1016/j.isci.2023.106984",
language = "English",
volume = "26",
journal = "iScience",
issn = "2589-0042",
publisher = "Elsevier",
number = "7",

}

RIS

TY - JOUR

T1 - Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1

AU - Rudjord-Levann, Asha M.

AU - Ye, Zilu

AU - Hafkenscheid, Lise

AU - Horn, Sabrina

AU - Wiegertjes, Renske

AU - Nielsen, Mathias A.I.

AU - Song, Ming

AU - Mathiesen, Caroline B.K.

AU - Stoop, Jesse

AU - Stowell, Sean

AU - Straten, Per Thor

AU - Leffler, Hakon

AU - Vakhrushev, Sergey Y.

AU - Dabelsteen, Sally

AU - Olsen, Jesper V.

AU - Wandall, Hans H.

N1 - Publisher Copyright: © 2023 The Authors

PY - 2023

Y1 - 2023

N2 - Galectins are a group of carbohydrate-binding proteins with a presumed immunomodulatory role and an elusive function on antigen-presenting cells. Here we analyzed the expression of galectin-1 and found upregulation of galectin-1 in the extracellular matrix across multiple tumors. Performing an in-depth and dynamic proteomic and phosphoproteomic analysis of human macrophages stimulated with galectin-1, we show that galectin-1 induces a tumor-associated macrophage phenotype with increased expression of key immune checkpoint protein programmed cell death 1 ligand 1 (PD-L1/CD274) and immunomodulator indoleamine 2,3-dioxygenase-1 (IDO1). Galectin-1 induced IDO1 and its active metabolite kynurenine in a dose-dependent manner through JAK/STAT signaling. In a 3D organotypic tissue model system equipped with genetically engineered tumorigenic epithelial cells, we analyzed the cellular source of galectin-1 in the extracellular matrix and found that galectin-1 is derived from epithelial and stromal cells. Our results highlight the potential of targeting galectin-1 in immunotherapeutic treatment of human cancers.

AB - Galectins are a group of carbohydrate-binding proteins with a presumed immunomodulatory role and an elusive function on antigen-presenting cells. Here we analyzed the expression of galectin-1 and found upregulation of galectin-1 in the extracellular matrix across multiple tumors. Performing an in-depth and dynamic proteomic and phosphoproteomic analysis of human macrophages stimulated with galectin-1, we show that galectin-1 induces a tumor-associated macrophage phenotype with increased expression of key immune checkpoint protein programmed cell death 1 ligand 1 (PD-L1/CD274) and immunomodulator indoleamine 2,3-dioxygenase-1 (IDO1). Galectin-1 induced IDO1 and its active metabolite kynurenine in a dose-dependent manner through JAK/STAT signaling. In a 3D organotypic tissue model system equipped with genetically engineered tumorigenic epithelial cells, we analyzed the cellular source of galectin-1 in the extracellular matrix and found that galectin-1 is derived from epithelial and stromal cells. Our results highlight the potential of targeting galectin-1 in immunotherapeutic treatment of human cancers.

KW - Cancer

KW - Immunology

U2 - 10.1016/j.isci.2023.106984

DO - 10.1016/j.isci.2023.106984

M3 - Journal article

C2 - 37534161

AN - SCOPUS:85161718499

VL - 26

JO - iScience

JF - iScience

SN - 2589-0042

IS - 7

M1 - 106984

ER -

ID: 360682643