Positioning Europe for the EPITRANSCRIPTOMICS challenge
Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › fagfællebedømt
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Positioning Europe for the EPITRANSCRIPTOMICS challenge. / Jantsch, Michael F; Quattrone, Alessandro; O'Connell, Mary; Helm, Mark; Frye, Michaela; Macias-Gonzales, Manuel; Ohman, Marie; Ameres, Stefan; Willems, Luc; Fuks, Francois; Oulas, Anastasis; Vanacova, Stepanka; Nielsen, Henrik; Bousquet-Antonelli, Cecile; Motorin, Yuri; Roignant, Jean-Yves; Balatsos, Nikolaos; Dinnyes, Andras; Baranov, Pavel; Kelly, Vincent; Lamm, Ayelet; Rechavi, Gideon; Pelizzola, Mattia; Liepins, Janis; Holodnuka Kholodnyuk, Irina; Zammit, Vanessa; Ayers, Duncan; Drablos, Finn; Dahl, John Arne; Bujnicki, Janusz; Jeronimo, Carmen; Almeida, Raquel; Neagu, Monica; Costache, Marieta; Bankovic, Jasna; Banovic, Bojana; Kyselovic, Jan; Valor, Luis Miguel; Selbert, Stefan; Pir, Pinar; Demircan, Turan; Cowling, Victoria; Schäfer, Matthias; Rossmanith, Walter; Lafontaine, Denis; David, Alexandre; Carre, Clement; Lyko, Frank; Schaffrath, Raffael; Schwartz, Schraga; Verdel, Andre; Klungland, Arne; Purta, Elzbieta; Timotijevic, Gordana; Cardona, Fernando; Davalos, Alberto; Ballana, Ester; O Carroll, Donal; Ule, Jernej; Fray, Rupert.
I: RNA Biology, Bind 15, Nr. 6, 2018, s. 829-831.Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › fagfællebedømt
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TY - JOUR
T1 - Positioning Europe for the EPITRANSCRIPTOMICS challenge
AU - Jantsch, Michael F
AU - Quattrone, Alessandro
AU - O'Connell, Mary
AU - Helm, Mark
AU - Frye, Michaela
AU - Macias-Gonzales, Manuel
AU - Ohman, Marie
AU - Ameres, Stefan
AU - Willems, Luc
AU - Fuks, Francois
AU - Oulas, Anastasis
AU - Vanacova, Stepanka
AU - Nielsen, Henrik
AU - Bousquet-Antonelli, Cecile
AU - Motorin, Yuri
AU - Roignant, Jean-Yves
AU - Balatsos, Nikolaos
AU - Dinnyes, Andras
AU - Baranov, Pavel
AU - Kelly, Vincent
AU - Lamm, Ayelet
AU - Rechavi, Gideon
AU - Pelizzola, Mattia
AU - Liepins, Janis
AU - Holodnuka Kholodnyuk, Irina
AU - Zammit, Vanessa
AU - Ayers, Duncan
AU - Drablos, Finn
AU - Dahl, John Arne
AU - Bujnicki, Janusz
AU - Jeronimo, Carmen
AU - Almeida, Raquel
AU - Neagu, Monica
AU - Costache, Marieta
AU - Bankovic, Jasna
AU - Banovic, Bojana
AU - Kyselovic, Jan
AU - Valor, Luis Miguel
AU - Selbert, Stefan
AU - Pir, Pinar
AU - Demircan, Turan
AU - Cowling, Victoria
AU - Schäfer, Matthias
AU - Rossmanith, Walter
AU - Lafontaine, Denis
AU - David, Alexandre
AU - Carre, Clement
AU - Lyko, Frank
AU - Schaffrath, Raffael
AU - Schwartz, Schraga
AU - Verdel, Andre
AU - Klungland, Arne
AU - Purta, Elzbieta
AU - Timotijevic, Gordana
AU - Cardona, Fernando
AU - Davalos, Alberto
AU - Ballana, Ester
AU - O Carroll, Donal
AU - Ule, Jernej
AU - Fray, Rupert
PY - 2018
Y1 - 2018
N2 - The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the ~150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.
AB - The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20 years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the ~150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.
KW - DNA, Neoplasm/genetics
KW - Epigenesis, Genetic
KW - Epigenomics/standards
KW - Europe
KW - Gene Expression Profiling/methods
KW - Gene Expression Regulation, Neoplastic
KW - Humans
KW - Neoplasms/genetics
KW - RNA, Neoplasm/genetics
KW - Transcriptome
U2 - 10.1080/15476286.2018.1460996
DO - 10.1080/15476286.2018.1460996
M3 - Comment/debate
C2 - 29671387
VL - 15
SP - 829
EP - 831
JO - R N A Biology
JF - R N A Biology
SN - 1547-6286
IS - 6
ER -
ID: 213161533