The small Cajal body-specific RNA 15 (SCARNA15) directs p53 and redox homeostasis via selective splicing in cancer cells

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Standard

The small Cajal body-specific RNA 15 (SCARNA15) directs p53 and redox homeostasis via selective splicing in cancer cells. / Beneventi, Giulia; Munita, Roberto; Cao Thi Ngoc, Phuong; Madej, Magdalena; Cieśla, Maciej; Muthukumar, Sowndarya; Krogh, Nicolai; Nielsen, Henrik; Swaminathan, Vinay; Bellodi, Cristian.

I: NAR Cancer, Bind 3, Nr. 3, zcab026, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Beneventi, G, Munita, R, Cao Thi Ngoc, P, Madej, M, Cieśla, M, Muthukumar, S, Krogh, N, Nielsen, H, Swaminathan, V & Bellodi, C 2021, 'The small Cajal body-specific RNA 15 (SCARNA15) directs p53 and redox homeostasis via selective splicing in cancer cells', NAR Cancer, bind 3, nr. 3, zcab026. https://doi.org/10.1093/narcan/zcab026

APA

Beneventi, G., Munita, R., Cao Thi Ngoc, P., Madej, M., Cieśla, M., Muthukumar, S., Krogh, N., Nielsen, H., Swaminathan, V., & Bellodi, C. (2021). The small Cajal body-specific RNA 15 (SCARNA15) directs p53 and redox homeostasis via selective splicing in cancer cells. NAR Cancer, 3(3), [zcab026]. https://doi.org/10.1093/narcan/zcab026

Vancouver

Beneventi G, Munita R, Cao Thi Ngoc P, Madej M, Cieśla M, Muthukumar S o.a. The small Cajal body-specific RNA 15 (SCARNA15) directs p53 and redox homeostasis via selective splicing in cancer cells. NAR Cancer. 2021;3(3). zcab026. https://doi.org/10.1093/narcan/zcab026

Author

Beneventi, Giulia ; Munita, Roberto ; Cao Thi Ngoc, Phuong ; Madej, Magdalena ; Cieśla, Maciej ; Muthukumar, Sowndarya ; Krogh, Nicolai ; Nielsen, Henrik ; Swaminathan, Vinay ; Bellodi, Cristian. / The small Cajal body-specific RNA 15 (SCARNA15) directs p53 and redox homeostasis via selective splicing in cancer cells. I: NAR Cancer. 2021 ; Bind 3, Nr. 3.

Bibtex

@article{ff9422bf449e43a59f947ab4e0854091,
title = "The small Cajal body-specific RNA 15 (SCARNA15) directs p53 and redox homeostasis via selective splicing in cancer cells",
abstract = "Small Cajal body-specific RNAs (scaRNAs) guide post-transcriptional modification of spliceosomal RNA and, while commonly altered in cancer, have poorly defined roles in tumorigenesis. Here, we uncover that SCARNA15 directs alternative splicing (AS) and stress adaptation in cancer cells. Specifically, we find that SCARNA15 guides critical pseudouridylation (Ψ) of U2 spliceosomal RNA to fine-tune AS of distinct transcripts enriched for chromatin and transcriptional regulators in malignant cells. This critically impacts the expression and function of the key tumor suppressors ATRX and p53. Significantly, SCARNA15 loss impairs p53-mediated redox homeostasis and hampers cancer cell survival, motility and anchorage-independent growth. In sum, these findings highlight an unanticipated role for SCARNA15 and Ψ in directing cancer-associated splicing programs.",
author = "Giulia Beneventi and Roberto Munita and {Cao Thi Ngoc}, Phuong and Magdalena Madej and Maciej Cie{\'s}la and Sowndarya Muthukumar and Nicolai Krogh and Henrik Nielsen and Vinay Swaminathan and Cristian Bellodi",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of NAR Cancer.",
year = "2021",
doi = "10.1093/narcan/zcab026",
language = "English",
volume = "3",
journal = "NAR Cancer",
issn = "2632-8674",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - The small Cajal body-specific RNA 15 (SCARNA15) directs p53 and redox homeostasis via selective splicing in cancer cells

AU - Beneventi, Giulia

AU - Munita, Roberto

AU - Cao Thi Ngoc, Phuong

AU - Madej, Magdalena

AU - Cieśla, Maciej

AU - Muthukumar, Sowndarya

AU - Krogh, Nicolai

AU - Nielsen, Henrik

AU - Swaminathan, Vinay

AU - Bellodi, Cristian

N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of NAR Cancer.

PY - 2021

Y1 - 2021

N2 - Small Cajal body-specific RNAs (scaRNAs) guide post-transcriptional modification of spliceosomal RNA and, while commonly altered in cancer, have poorly defined roles in tumorigenesis. Here, we uncover that SCARNA15 directs alternative splicing (AS) and stress adaptation in cancer cells. Specifically, we find that SCARNA15 guides critical pseudouridylation (Ψ) of U2 spliceosomal RNA to fine-tune AS of distinct transcripts enriched for chromatin and transcriptional regulators in malignant cells. This critically impacts the expression and function of the key tumor suppressors ATRX and p53. Significantly, SCARNA15 loss impairs p53-mediated redox homeostasis and hampers cancer cell survival, motility and anchorage-independent growth. In sum, these findings highlight an unanticipated role for SCARNA15 and Ψ in directing cancer-associated splicing programs.

AB - Small Cajal body-specific RNAs (scaRNAs) guide post-transcriptional modification of spliceosomal RNA and, while commonly altered in cancer, have poorly defined roles in tumorigenesis. Here, we uncover that SCARNA15 directs alternative splicing (AS) and stress adaptation in cancer cells. Specifically, we find that SCARNA15 guides critical pseudouridylation (Ψ) of U2 spliceosomal RNA to fine-tune AS of distinct transcripts enriched for chromatin and transcriptional regulators in malignant cells. This critically impacts the expression and function of the key tumor suppressors ATRX and p53. Significantly, SCARNA15 loss impairs p53-mediated redox homeostasis and hampers cancer cell survival, motility and anchorage-independent growth. In sum, these findings highlight an unanticipated role for SCARNA15 and Ψ in directing cancer-associated splicing programs.

U2 - 10.1093/narcan/zcab026

DO - 10.1093/narcan/zcab026

M3 - Journal article

C2 - 34316713

VL - 3

JO - NAR Cancer

JF - NAR Cancer

SN - 2632-8674

IS - 3

M1 - zcab026

ER -

ID: 299817503