Melanie Blasius
Lektor
Molecular Aging Program
Blegdamsvej 3
2200 København N.
The overarching aim for the group (Bekker-Jensen Group) is to understand the molecular details of cellular stress responses and how they contribute to human diseases such as cancer and aging-related maladies. We are especially interested in understanding the mechanisms by which the MAP kinases p38 and JNK become activated in response to cellular stress insults such as ribosomal impairment, oxidative stress and high osmolarity, and how such signaling drives or protect against pathological cellular changes. Importantly, the same signaling pathways are crucial for inflammatory responses, adding to the relevance of our work for a range of human diseases.
ID: 170617872
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GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling
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P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress
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ZAKβ is activated by cellular compression and mediates contraction-induced MAP kinase signaling in skeletal muscle
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