Carbohydrate clearance receptors in transfusion medicine
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Complex carbohydrates play important functions for circulation of proteins and cells. They provide protective shields and refraction from non-specific interactions with negative charges from sialic acids to enhance circulatory half-life. For recombinant protein therapeutics carbohydrates are especially important to enhance size and reduce glomerular filtration loss. Carbohydrates are, however, also ligands for a large number of carbohydrate-binding lectins exposed to the circulatory system that serve as scavenger receptors for the innate immune system, or have more specific roles in targeting of glycoproteins and cells.
Originalsprog | Engelsk |
---|---|
Tidsskrift | BBA General Subjects |
Vol/bind | 1820 |
Udgave nummer | 11 |
Sider (fra-til) | 1797-808 |
Antal sider | 12 |
ISSN | 0304-4165 |
DOI | |
Status | Udgivet - jul. 2012 |
ID: 40840661