Research Programs

Insight into morphogenesis and differentiation is crucial for the understanding of normal organ development and pathogenesis including development of cancer. This program focuses on the underlying cellular and molecular mechanisms. Our research topics include stem cell biology, proteins and lipids in membrane domains including their trafficking and sorting, receptors and cell signalling.  >>

This program focuses on an exposition of the fundamental principles of human genetics with an emphasis on the genes and molecular mechanisms operating in human disease. Our research includes general principles of disease inheritance, pathogenesis, diagnosis, counselling, and therapy. >>

Nucleic acids are at the center of gene expression and control, both in terms of the genome (the DNA) itself and through expressed coding (messenger) and non-coding (micro and structural) RNAs. This program is focusing on posttranscriptional RNA modification (e.g. in ribosomal RNA), functional aspects of DNA conformation, and on principles of genetic therapeutic approaches, specifically exploiting peptide nucleic acids (PNA) within antibiotics and muscular dystrophy. >>

Glycosylation is one of the most abundant forms of posttranslational modifications. Glycans play a wide array of different biological roles from direct effects on folding, processing, sorting, and functions of proteins, to serving as ligands in important adhesion events for cell-cell interactions. The Copenhagen Center for Glycomics focuses on the importance of glycans in biology and translating such findings into new tools to monitor and treat human disease. >>

Our research topics include analysis of human genetic disorders associated with premature aging and cancer predisposition, the role of homologous recombination in suppression of chromosomal instability, the role of DNA repair pathways in ensuring faithful DNA replication and chromosome segregation as well as cellular stress signaling, mitochondrial functions, mitochondrial genome stability, DNA repair, and changes with aging >>