primary research areas
Angiogenesis, Lymphangiogenesis, Inflammation, Interleukins, Cell signaling
We are currently studying potential effects of IL-20 in combinations with other cytokines on signaling processes in vascular endothelial cells, with special focus on the anti-angiogenic cytokine IL-24, which binds to the same receptor complexes as IL-20. In addition we are investigating the role of IL-20, IL-24 and IL-7 in lymphangiogenesis using a newly developed immortalized lymphatic cell line.
Research activities are divided into 4 areas:
Characterization of IL-20, IL-24 and IL-7 activated cellular signaling in vascular and lymphatic endothelial cells.
Effects of IL-20 and IL-24 on the expression levels of pro- and anti-angiogenic factors.
The role of PDGF-BB, FGF and VEGF-C in vessel formation by lymphatic endothelial cells.
Development and application of fluorescent tools for studying protein kinase activities.
Steen Dissing, professor, Dept. of Cellular and Molecular Medicine, Copenhagen University
Yihai Cao, professor, Karolinska Institute, Sweden
Vilhelm Bohr, professor, NIH, Baltimore
Lucia Morbidelli, associate professor, University of Sienna, Italy
Peter Staller, associate professor, Biotech Research & Innovation Centre (BRIC), Copenhagen.
Course administrator and teacher at “Course in Medical Cell- and Tissue Biology”
Cell Biology for molecular biomedicine students, medical and dental students.
Hammer T, Tritsaris K, Hübschmann MV, Gibson J, Nisato RE, Pepper MS, Dissing S.
IL-20 activates human lymphatic endothelial cells causing cell signalling and tube formation.
Microvasc Res. 2009 Mar 9. PMID: 19281830
Rahbek UL, Dissing S, Thomassen C, Hansen AJ, Tritsaris K.
Nerve growth factor activates aorta endothelial cells causing PI3K/Akt- and ERK-dependent migration.
Pflugers Arch. 2005 Aug;450(5):355-61. PMID: 15924236