Petersen/Villadsen Group

The aim of research in the group is to dissect stem cell hierarchies in the normal human breast and in breast cancer, with a view to finding the cell of origin in different breast cancer subtypes.

 

 

 

 

 

 

 

 

 

 

 

 

 

  • Kohler KT, Goldhammer N, Demharter S, Pfisterer U, Khodosevich K, Rønnov-Jessen L, Petersen OW, Villadsen R, Kim J. Ductal keratin 15+ luminal progenitors in normal breast exhibit a basal-like breast cancer transcriptomic signature (IF 7.5). NPJ Breast Cancer. 2022 Jul 12;8(1):81. doi: 10.1038/s41523-022-00444-8.
  • Goldhammer N, Kim J, Villadsen R, Rønnov-Jessen L, Petersen OW. Myoepithelial progenitors as founder cells of hyperplastic human breast lesions upon PIK3CA transformation (IF 6.5). Commun Biol. 2022 Mar 10;5(1):219. doi: 10.1038/s42003-022-03161-x
  • Engelsen AST, Wnuk-Lipinska K, Bougnaud S, Pelissier Vatter FA, Tiron C, Villadsen R, Miyano M, Lotsberg ML, Madeleine N, Panahandeh P, Dhakal S, Tan TZ, Peters SD, Grøndal S, Aziz SM, Nord S, Herfindal L, Stampfer MR, Sørlie T, Brekken RA, Straume O, Halberg N, Gausdal G, Thiery JP, Akslen LA, Petersen OW, LaBarge MA, Lorens JB. AXL Is a Driver of Stemness in Normal Mammary Gland and Breast Cancer (IF 6.1). iScience. 2020 Oct 7;23(11):101649. doi: 10.1016/j.isci.2020.101649. eCollection 2020 Nov 20.
  • Morsing M, Kim J, Villadsen R, Goldhammer N, Jafari A, Kassem M, Petersen OW, Rønnov-Jessen L. Fibroblasts direct differentiation of human breast epithelial progenitors (IF 8.4). Breast Cancer Res. 2020 Sep 29;22(1):102. doi: 10.1186/s13058-020-01344-0.
  • Goldhammer N, Kim J, Timmermans-Wielenga V, Petersen OW. Characterization of organoid cultured human breast cancer (IF 8.4). Breast Cancer Res. 2019 Dec 11;21(1):141. doi: 10.1186/s13058-019-1233-x.
  • Bagger SO, Hopkinson BM, Pandey DP, Bak M, Brydholm AV, Villadsen R, Helin K, Rønnov-Jessen L, Petersen OW, Kim J. Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity (IF 41). Mol Cancer. 2018 Dec 10;17(1):171. doi: 10.1186/s12943-018-0918-6.
  • Eichenlaub T, Villadsen R, Freitas FCP, Andrejeva D, Aldana BI, Nguyen HT, Petersen OW, Gorodkin J, Herranz H, Cohen SM. Warburg Effect Metabolism Drives Neoplasia in a Drosophila Genetic Model of Epithelial Cancer (IF 10.9). Curr Biol. 2018 Oct 22;28(20):3220-3228.e6. doi: 10.1016/j.cub.2018.08.035. Epub 2018 Oct 4.
  • Fridriksdottir AJ, Villadsen R, Morsing M, Klitgaard MC, Kim J, Petersen OW, Rønnov-Jessen L. Proof of region-specific multipotent progenitors in human breast epithelia (IF 12.8). Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10102-E10111. doi: 10.1073/pnas.1714063114. Epub 2017 Nov 6.

 

 

Group Leaders

ole william petersenOle William Petersen
Professor of Tissue Morphology and Differentiation, DSc
Head of the Body Donation Programme
owp@sund.ku.dk

(+45) 35 32 72 84 / (+45) 28 75 72 84
CV, publications, etc for Ole William Petersen   

 

rene villadsenRené Villadsen
Associate Professor
renev@sund.ku.dk  

(+45) 29 62 33 63 / (+45) 35 33 55 89
CV, publications, etc for René Villadsen 

 

 

Morphogenesis and Differentiation Program