Tritsaris/Dissing Group – University of Copenhagen

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Department of Cellular and Molecular Medicine > Research Groups > Tritsaris/Dissing Group

Tritsaris/Dissing Group

Morphogenesis and Differentiation Program

Research areas

Angiogenesis, Lymphangiogenesis, Inflammation, Interleukins, Cell signaling

Current research areas

Participants

Katerina Tritsaris (associate Professor), Steen Dissing (professor), Carina Lynnerup Pedersen (technician), Mohammad Taha Yassin (post.doc).

Collaborators

Dr. Reinhold Medina, Queen’s University, Belfast, UK.
Eva Løbner Lund, Neuropathologist MD, Dept of Pathology, Copenhagen University Hospital.
Torben Lykke Sørensen, Associate Professor, MD, Copenhagen University Hospital Roskilde.
Yihai Cao, professor, Karolinska Institute, Sweden.
Niels Erik Skakkebæk, Professor dr. med., Copenhagen University Hospital.
Martin Blomberg, associate professor, dr. med., Copenhagen University Hospital.

Research based teaching

Our group is teaching medical, odontology and molecular biomedicine undergraduate students in cell biology. In addition, we supervise 2-4 molecular biomedicine bachelor and master students per year. Katerina Tritsaris is vice head of studies of molecular biomedicine and administrator of the course “Medical cell and tissue biology. 

Recent publications

  • Rehfeld A, Egeberg D, Almstrup K, Holm Petersen J, Dissing S, Skakkebæk NE. Chemical UV filters can affect human sperm function in a progesterone-like manner. Endocr Connect. 2017 Sep 5.

  • Lykke K, Assentoft M, Hørlyck S, Helms HC, Stoica A, Toft-Bertelsen TL, Tritsaris K, Vilhardt F, Brodin B, MacAulay N. Evaluating the involvement of cerebral microvascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration.  J Cereb Blood Flow Metab. 2017 Jan. 

  • Pedersen AK, Mendes Lopes de Melo J, Mørup N, Tritsaris K, Pedersen SF. Tumor microenvironment conditions alter Akt and Na+/H+ exchanger NHE1 expression in endothelial cells more than hypoxia alone: implications for endothelial cell function in cancer. BMC Cancer. 2017 Aug 14;17(1):542.

  • Egholm C, Khammy MM, Dalsgaard T, Mazur A, Tritsaris K, Hansen AJ, Aalkjaer C, Dissing S. GLP-1 inhibits VEGFA-mediated signaling in isolated human endothelial cells and VEGFA-induced dilation of rat mesenteric arteries.  Am J Physiol Heart Circ Physiol. 2016 Nov 1;311(5):H1214-H1224.

Selected publications

  • Egholm C, Khammy MM, Dalsgaard T, Mazur A, Tritsaris K, Hansen AJ, Aalkjaer C, Dissing S. GLP-1 inhibits VEGFA-mediated signaling in isolated human endothelial cells and VEGFA-induced dilation of rat mesenteric arteries.  Am J Physiol Heart Circ Physiol. 2016 Nov 1;311(5):H1214-H1224.
     
  • Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, Yang X, Nakamura M, Wang J, Zhuang R, Morikawa H, Xue Y, Braun H, Beyaert R, Samani N, Nakae S, Hams E, Dissing S, Fallon PG, Langer R, Cao Y. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages.  Nat Commun. 2016,  7:11385-11403.

  • Straasø B, Lauritzen L, Lunde M, Vinberg M, Lindberg L, Larsen ER, Dissing S, Bech P.  Dose-remission of pulsating electromagnetic fields as augmentation in therapy-resistant depression: a randomized, double-blind controlled study. Acta Neuropsychiatr. 2014 Oct;26(5):272-9.

  • Bosteen MH, Tritsaris K, Hansen AJ, Dissing S. IL-17A potentiates TNFα-induced secretion from human endothelial cells and alters barrier functions controlling neutrophils rights of passage. Pflugers Arch. 2014 466(5):961-72.

  • Nielsen SR, Hammer T, Gibson J, Pepper MS, Nisato RE, Dissing S, Tritsaris K. IL-27 inhibits lymphatic endothelial cell proliferation by STAT1-regulated gene expression. Microcirculation. 2013 Aug;20(6):555-64.

  • Blomberg Jensen M, Dissing S. Non-genomic effects of vitamin D in human spermatozoa.  Steroids. 2012 Aug;77(10):903-9.

  • Cao R, Xue Y, Hedlund EM, Zhong Z, Tritsaris K, Tondelli B, Lucchini F, Zhu Z, Dissing S, Cao Y. VEGFR1-mediated pericyte ablation links VEGF and PlGF to cancer-associated retinopathy.  Proc Natl Acad Sci USA. 2010 Jan 12;107(2):856-61.

  • Hammer T, Tritsaris K, Hübschmann MV, Gibson J, Nisato RE, Pepper MS, Dissing S. IL-20 activates human lymphatic endothelial cells causing cell signalling and tube formation.  Microvasc Res. 2009 Jun;78(1):25-32.

  • Tritsaris K, Myren M, Ditlev SB, Hübschmann MV, van der Blom I, Hansen AJ, Olsen UB, Cao R, Zhang J, Jia T, Wahlberg E, Dissing S, Cao Y. IL-20 is an arteriogenic cytokine that remodels collateral networks and improves functions of ischemic hind limbs.  Proc Natl Acad Sci USA. 2007 104(39):15364-9.

  • Thamsborg G, Florescu A, Oturai P, Fallentin E, Tritsaris K, Dissing S. Treatment of knee osteoarthritis with pulsed electromagnetic fields: a randomized, double-blind, placebo-controlled study.  Osteoarthritis Cartilage. 2005 Jul;13(7):575-81.

  • Rahbek UL, Dissing S, Thomassen C, Hansen AJ, Tritsaris K. Nerve growth factor activates aorta endothelial cells causing PI3K/Akt- and ERK-dependent migration.  Pflugers Arch. 2005 450(5):355-61.

  • Cao R, Björndahl MA, Religa P, Clasper S, Garvin S, Galter D, Meister B, Ikomi F, Tritsaris K, Dissing S, Ohhashi T, Jackson DG, Cao Y. PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis.  Cancer Cell. 2004 6(4):333-45