I have a mechanistic interest into tissue-specific gene expression and its genome-wide and locus specific regulation by non-coding RNAs, epigenetic modifications especially methylation and hydroxymethylation and 3D-organization of the genome within the nucleus. The interaction of these mechanisms especially in the brain is our primary interest.
As well as the mechanisms, I am interested in developing methods based on in situ hybridization both at RNA and DNA level. I am involved in different interdisciplinary projects that involve either nanotechnology where we establishing lab-on-a-chip devices for in situ hybridization or DNA sequencing, or chemistry where we establish methods with new synthetic probe chemistries.
We are a member of the 3D-Nucleus Group.
- In situ hybridization
- Non-coding RNAs