H Nielsen Group

• The flexibility and evolutionary adaptability of RNA-guided nucleotide modifications
• Specialized ribosomes (including cancer ribosomes)
• The role of helicases in ribosome biogenesis
• New RNA cap structures
• The lariat capping ribozyme
• Characterization of the circularization pathway in group I introns

• Anders Lund and Martin Jansson (BRIC, Copenhagen)
• Kirsten Grønbæk and Fazila Asmar (Copenhagen)
• Markus Bohnsack (Göttingen) and Nick Watkins (Newcastle)
• Jérôme Cavaillé (Toulouse)
• Carsten Geisler and Martin Kongsbak-Wismann (Copenhagen) and Monika Wolkers (Amsterdam)
• Daniel Wilson and Bertrand Beckert (Hamborg)
• Steinar D. Johansen and Igor Babiak (Bodø)

More than 30 years of experience in teaching of cell biology and RNA biology at bachelor and masters level. Organizer of  >20 experimental ph. d. courses. Considerable experience in dissemination of science to the general public.

• Nielsen, H., Westhof, E., and Johansen, S.: An mRNA is capped with a 2’, 5’ lariat catalyzed by a group I-like ribozyme. Science 309, 1584-1589 (2005).
  
  
• Beckert, B., Nielsen, H.^*, Einvik, C., Johansen, S. D., Westhof, E., and Masquida, B.^*: Molecular modelling of the GIR1 branching ribozyme gives new insight into evolution of structurally related ribozymes. EMBO Journal 27, 667-78 (2008).[^*Co-corresponding authors]
   
• Meyer, M., Nielsen, H., Oliéric, V., Roblin, P., Johansen, S.D., Westhof, E., and Masquida, B.: Speciation of a group I intron into a lariat capping ribozyme. Proc Natl Acad Sci USA 111 (21): 7659-7664 (2014).
• Birkedal, U., Christensen-Dalsgaard, M., Krogh, N., Sabarinathan, R., Gorodkin, J., and Nielsen, H.: Profiling of ribose methylations in RNA by high-throughput sequencing. Angew Chem Int Ed Engl. 54(2):451-5 (2015).
  
  
• Krogh N, Jansson M.D., Häfner S.J., Tehler D., Birkedal U., Christensen-Dalsgaard M., Lund A.H., Nielsen H.: Profiling of 2'-O-Me in human rRNA reveals a subset of fractionally modified positions and provides evidence for ribosome heterogeneity. Nucleic Acids Res. 44:7884-95 (2016).
  
  
• Seistrup K.H., Rose, S., Birkedal, U., Nielsen, H., Huber, H., and Douthwaite, S.: Bypassing rRNA methylation by RsmA/Dim1 during ribosome maturation in the hyperthermophilic archaeon Nanoarchaeum equitans. Nucleic Acids Res. 45:2007-2015.
• Krogh, N., Pietschmann, M., Schmid, M., Jensen, T.H., Nielsen, H.: Lariat capping as a tool to manipulate the 5’ end of individual yeast mRNA species in vivo. RNA 23:683-695. (2017).