Vilhardt Group

By in vitro studies the Vilhardt Group try to approach fundamental unit operations in neuroinflammation and neurodegenerative disease with the aim of obtaining mechanistic insight.

NBMG fungus tubulin

 

 

 

 

The lab has a long-standing interest in NADPH oxidase (NOX2) trafficking and function in macrophages and microglia (glia and macrophage cell of the CNS), and we continue to pursue the intricacies of NOX2 trafficking in the cell.

We are also interested in autophagy and the workings of the endosomal pathway in neurons under conditions of neurodegenerative cell stress, and recently our focus is on the ESCRT complex in endosomal and nuclear phenotypes of disease.

Brain-associated macrophages, including microglia, are important immune cells in neuroinflammation and we have recently engaged in a long-term collaboration with the Neurosurgical Department at Rigshospitalet, Copenhagen to investigate tumor-associated macrophages and their role in meningioma progression and post-operative morbidity.

 

 

 

  • NADPH Oxidase trafficking and function in macrophages
  • The ESCRT complex in frontotemporal dementia and spastic paraplegia
  • Tumor-associated macrophages in meningioma

 

 

  1. Blum N, Mirian C, Maier AD, Mathiesen TI, Vilhardt F, Haslund-Vinding JL. Translocator protein (TSPO) expression in neoplastic cells and tumor-associated macrophages in meningiomas. J Neuropathol Exp Neurol. 82, 1020-1032 (2023). 
  2. Zang J, Peters F, Cambet Y, Cifuentes-Pagano E, Hissabu MMS, Dustin CM, Svensson LH, Olesen MM, Poulsen MFL, Jacobsen S, Tuelung PS, Narayanan D, Langkilde AE, Gajhede M, Pagano PJ, Jaquet V, Vilhardt F, Bach A. Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors. Journal of Medicinal Chemistry 66, 14963 (2023).
  3. Borland H, Rasmussen I, Bjerregaard-Andersen K, Rasmussen M, Olsen A, Vilhardt F. α-synuclein buildup is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25α. Journal of Biological Chemistry 298, 102531 (2022).
  4. Haslund-Vinding J, Møller JR, Ziebell M, Vilhardt F, Mathiesen T. The role of systemic inflammatory cells in meningiomas. Neurosurgical Reviews 45, 1205-1215 (2022).
  5. Villegas L, Nørremølle A, Freude K, Vilhardt F. Nicotinamide Adenine Dinucleotide Phosphate Oxidases Are Everywhere in Brain Disease, but Not in Huntington's Disease? Frontiers in Aging Neuroscience 5, 736734 (2021).

 

 

 

 

 

 

 

We are currently funded by:

  • Aage og Johanne Louis-Hansens Fond
  • Læge Sofus Carl Emil Friis og hustru Olga Doris Fond
  • NEYE-fonden

Neye fonden logo

 

 

 

frederik vilhardtGroup Leader

Frederik Vilhardt
associate professor
vilhardt@sund.ku.dk  

(+45) 25 43 22 00 / (+45) 35 32 71 20
CV, Publications, etc

Morphogenesis and Differentiation Program