LA Larsen Group

We are interested in understanding the fundamental aspects of human embryonic development and birth defects. Our main research focus is genetic and functional aspects of human cardiac development and congenital heart disease.

functional analyses in tissues and models

 

 

 

 

 

 

 

 

 

 

 

 

 

  • Audain E, Wilsdon A, Breckpot J, Izarzugaza JMG, Fitzgerald TW, Kahlert AK, Sifrim A, Wünnemann F, Perez-Riverol Y, Abdul-Khaliq H, Bak M, Bassett AS, Belmont JW, Benson DW, Berger F, Daehnert I, Devriendt K, Dittrich S, Daubeney P, Garg V, Hackmann K, Hoff K, Hofmann P, Dombrowsky G, Pickardt T, Bauer U, Keavney BD, Klaassen S, Kramer HH, Marshall CR, Milewicz DM, Lemaire SA, Coselli J, Mitchell ME, Tomita-Mitchell A, Prakash SK, Stamm K, Stewart AFR, Silversides CK, Siebert R, Stiller B, Rosenfeld JA, Vater I, Postma AV, Caliebe A, Brook JD, Andelfinger G, Hurles ME, Thienpont B, Larsen LA, Hitz MP (2021) Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease. PLoS Genet 17:e1009679

  • Farooq M, Lindbæk L, Krogh N, Doganli C, Keller C, Mönnich M, Sakthivel S, Mang Y, Fatima A, Andersen VS, Hussain MS, Eiberg H, Hansen L, Kjaer KW, Gopalakrishnan J, Pedersen LB, Møllgård K, Nielsen H, Baig SM, Tommerup N, Christensen ST and Larsen LA (2020) RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia and neurogenesis. Nat Commun 11:5816. 

  • Izarzugaza JMG, Ellesøe SG, Doganli C, Ehlers NS, Dalgaard MD, Audain E, Dombrowsky G, Banasik K, Sifrim A, Wilsdon A, Thienpont B, Breckpot J, Gewillig M, Competence Network for Congenital Heart Defects Germany, Brook JD, Hitz MP, Larsen LA, Brunak S (2020) Systems genetics analysis identifies calcium signaling defects as novel cause of congenital heart disease. Genome Med 12:76.

  • Schroeder AM, Allahyari M, Vogler G, Missinato MA, Nielsen T, Yu MS, Theis JL, Larsen LA, Goyal P, Rosenfeld J, Nelson TJ, Olson TM, Colas AR, Grossfeld P, Bodmer R (2019) Model System Identification of Novel Congenital Heart Disease Gene Candidates: focus on RPL13. Hum Mol Genet 28:3954-3969.
  • Ellesøe SG, Workman CT, Bouvagnet P, Loffredo CA, McBride KL, Hinton RB, van Engelen K, Gertsen EC, Mulder BJM, Postma AV, Anderson RH, Hjortdal VE, Brunak S, Larsen LA (2018) Familial co-occurrence of congenital heart defects follows distinct patterns. Eur Heart J 39:1015-22.
  • Mönnich M, Borgeskov L, Breslin L, Jakobsen L, Rogowski M, Doganli C, Schrøder JM, Mogensen JB, Blinkenkjær L, Harder LM, Lundberg E, Geimer S, Christensen ST, Andersen JS, Larsen LA, Pedersen LB (2018) CEP128 localizes to the subdistal appendages of the mother centriole and regulates TGF-β/BMP signaling at the primary cilium. Cell reports 22:2584-2592.
  • Schmid F, Schou KB, Vilhelm MJ, Holm MS, Breslin L, Farinelli P, Larsen LA, Andersen JS, Pedersen LB, Christensen ST (2018) IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases. J Cell Biology 217:151-161.
  • Andersen TA, Troelsen KDL, Larsen LA (2014) Of Mice and Men: Molecular Genetics of Congenital Heart Disease. Cell Mol Life Sci 71:1327-52
  • Clement CA, Ajbro KD, Koefoed K, Vestergaard ML, Veland IR, Henriques de Jesus MP, Pedersen LB, Benmerah A, Andersen CY, Larsen LA, Christensen ST (2013) TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium. Cell Reports 3:1806-14.
  • Lage K, Greenway S, Rosenfeld JA, Wakimoto H, Gorham JM, Segre A,  Roberts AE, Smoot LB, Pu WT, Pereira AC, Mesquita SM, Tommerup N, Brunak S, Ballif BC, Schaffer L, Donahoe PK, Daly MJ, Seidman JG, Seidman CE and Larsen LA (2012) Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development. Proc Natl Acad Sci U S A 109:14035-40.
  • Thienpont B, Zhang L, Postma AV, Breckpot J, Tranchevent L-C, Van Loo P, Møllgård K, Tommerup N, Bache I, Tümer Z, van Engelen K, Menten B, Mortier G, Waggoner D, Gewillig M, Moreau Y, Devriendt K and Larsen LA (2010) Haplo-insufficiency of TAB2 causes congenital heart defects in humans. Am J Hum Genet 86:1-11.
  • Lage K, Møllgård K, Greenway S, Wakimoto H, Gorham JM, Workman CT, Bendsen E, Hansen NT, Rigina O, Roque FS, Wiese C, Christoffels VM,  Roberts AE, Smoot LB, Pu WT, Donahoe PK, Tommerup N, Brunak S, Seidman CE, Seidman JG and Larsen LA (2010) Dissecting spatio-temporal protein networks driving human heart development and related disorders. Mol Syst Biol 6:381.
  • Clement CA, Kristensen SG, Møllgård K, Yoder B, Pazour GJ, Larsen LA and Christensen ST (2009) The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation. J Cell Sci 122:3070-3082.
  • Erdogan F, Larsen LA, Zhang L, Tümer Z, Tommerup N, Chen W, Jacobsen JR, Schubert M, Jurkatis J, Tzschach A, Ropers H-H and Ullmann R. (2008) High frequency of submicroscopic genomic aberrations detected by tiling path array CGH in patients with isolated congenital heart disease. J Med Genet 45:704-709.

 

 

foto af lars allan larsenGroup Leader

Lars Allan Larsen
Professor of Developmental Genetics
larsal@sund.ku.dk  

(+45) 35 32 78 27
CV, publications, etc

 

Medical Genetics Program