Hickson Group

Our laboratory investigates the biochemical, molecular and cell biological functions of DNA repair factors in eukaryotic cells and how these factors act to maintain chromosome stability.

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  • Macheret, M., Bhowmick, R., Sobkowiak, K., Padayachy, L., Mailler, J., Hickson, I.D.* and Halazonetis, T.D.* (2020) High resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing. Cell Research, 30, 997-1008, *Co-corresponding authors.

  • Xing, M., Zhang, F., Liao, H., Chen, S., Che, L., Wang, X., Bao, Z., Ji, F., Chen, G., Zhang, H., Li, W., Chen, Z., Liu, Y., Hickson, I.D.*, Shen, H.* and Ying, S.* (2020) Replication stress induces ATR/CHK1-dependent non-random segregation of damaged chromosomes. Molecular Cell, 78, 714-724. *Co-corresponding authors.
     
  • Wu, W., Bhowmick, R., Özer, Ö., Vogel, I., Thakur, R.S., Richter, P.H., Ren, L., Hickson, I.D.* and Liu, Y.* (2020) RTEL1 resolves conflicts between DNA replication and transcription. Nature Struct. Molec. Biol., 27, 424-437. *Co-corresponding authors

  • Bizard, A.H., Allemand, J-F., Hassenkam, T., Paramasivam, M., Sarlós, K., Singh, M.I. and Hickson, I.D. (2019) PICH and TOP3A cooperate to induce positive DNA supercoiling. Nature Struct. Molec. Biol., 26, 267-274.
     
  • Sarlós, K., Biebricher, A.S., Bizard, A.H., Bakx, J.A.M., Ferrete-Bonastre, A.G., Modesti, M., Paramasivam, M., Yao, Q., Peterman, E.J.G., Wuite, G.J.L. and Hickson, I.D. (2018) Reconstitution of anaphase DNA bridge recognition and disjunction in vitro. Nature Struct. Molec. Biol., 25, 868-876.
     
  • Bhowmick, R., Minocherhomji, S. and Hickson, I.D. (2016) RAD52 facilitates mitotic DNA synthesis following replication stress. Molecular Cell, 64, 1117-1126.
  • Minocherhomji, S., Ying, S., Bjerregaard, V.A., Bursomanno, S., Aleliunaite, A., Wu, W., Mankouri, H.W., Shen, H., Liu, Y. and Hickson, I.D. (2015) Replication stress activates DNA repair synthesis in mitosis. Nature 528, 286-290.
  • Nielsen, C.F., Huttner, D., Bizard, A.H., Hirano, S., Li, T-N., Palmai-Pallag, T., Bjerregaard, V.A., Liu, Y., Nigg, E.A., Wang, L.H-C. and Hickson, I.D. (2015) PICH promotes sister chromatid disjunction in mitosis: evidence of functional co-operation with topoisomerase II. Nature Communications 6, 8962..

  • Ying, S., Minocherhomji, S., Chan, K.L., Palmai-Pallag, T., Chu, W.K., Wass, T., Mankouri H.W., Liu, Y. and Hickson, I.D. (2013) MUS81 promotes common fragile site expression. Nature Cell Biology 15, 1001-1007.
  • Biebricher, A., Hirano, S., Enzlin, J.H., Wiechens, N., Streicher, W.W., Huttner, D., Wang, L.H-H., Nigg, E.A., Owen-Hughes, T., Liu, Y., Peterman, E., Wuite, G.J.L. and Hickson, I.D. (2013) PICH: A DNA translocase Specially Adapted for Processing Anaphase Bridge DNA. Molecular Cell 51, 691-701.

  • Chan, K-L., Palmai-Pallag, T., Ying, S. and Hickson, I.D. (2009) Replication stress induces sister-chromatid bridging at fragile site loci in mitosis. Nature Cell Biology. 11, 753-760.

  • Chu, W-K. and Hickson, I.D. (2009) RecQ helicases: multifunctional genome caretakers. Nature Reviews Cancer 9, 644-654