Jafari group

The focus of our lab is to understand the mechanisms that regulate differentiation of skeletal stem cells to osteoblast and adipocyte lineages, and to investigate the relevance of these regulatory mechanisms to pathogenesis of bone loss in the context of inflammation, cancer, and aging.

dekorativt bilede




  • Regulatory mechanisms of skeletal (mesenchymal) stem cell (MSC) fate specification
  • Role of lysosomal proteases in regulation of bone and systemic energy homeostasis
  • Role of MSC-secreted factors in pathogenesis of bone loss in the context of aging, cancer, and inflammation
  • Role of bone marrow adipose tissue in regulation of skeletal homeostasis








  • Ali D, Tencerova M, Figeac F, Kassem M, Jafari A. The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men: The mechanisms and roles of increased bone marrow adiposity (IF: 6.1). Front Endocrinol (Lausanne). 2022 Sep 15;13:981487. doi: 10.3389/fendo.2022.981487.
  • Nordgaard C, Vind A, Brown A, Kjøbsted R, Snieckute G, Blasius M, Reinert M, Bekker-Jensen D, Del Val A, Haahr P, Antas P, Falk S, Perrier-Goult E, Tiedje C, Li X, Jørgensen N, Wojtaszewski J, Mallein-Gerin F, Andersen J, Pennisi C, Clemmensen C, Li V, Jafari A, Brummelkamp B, Olsen J, Blanco G, Bekker-Jensen S. ZAK-beta is activated by cell compression and mediates contraction-induced MAPK signaling in muscle (IF: 13.8). EMBO J. 2022 Sep 1;41(17):e111650. doi: 10.15252/embj.2022111650. Epub 2022 Jul 28.
  •  Jafari A, Fairfield H, Andersen TL, Reagan MR. Myeloma-bone marrow adipocyte axis in tumor survival and treatment response (IF: 9.1). Br J Cancer 2021 Sep;125(6):775-777. doi: 10.1038/s41416-021-01371-4. Epub 2021 Apr 15.
  •  Skov-Jeppesen K, Hepp N, Oeke J, Hansen MS, Jafari A, Svane MS, Balenga N, Olson J, Frost M, Kassem M, Madsbad S, Jensen JB, Holst JJ, Rosenkilde MM, Hartmann B. The antiresorptive effect of GIP, but not GLP-2, is preserved in patients with hypoparathyroidism (IF: 6.3). J Bone Miner Res. 2021 Aug;36(8):1448-1458.
  •  Fairfield H, Dudakovic A, Khatib CM, Farrell M, Costa S, Falank C, Hinge M, Murphy C, DeMambro V, Pettitt JA, Lary CW, Driscoll H, McDonald M, Kassem M, Rosen C, Andersen TL, Van Wijnen A, Jafari A, Reagan M. Myeloma-modified adipocytes exhibit metabolic dysfunction and a senescent-associated secretory phenotype (IF: 13.3).  Cancer Res. 2021 Feb 1;81(3):634-647. doi: 10.1158/0008-5472.CAN-20-1088. Epub 2020 Nov 20.
  •  Morsing M, Kim J, Villadsen R, Goldhammer N, Jafari A, Kassem M, Petersen OW, Ronnov-Jessen L. Fibroblast cell lines direct lobular-like and ductal-like differentiation of human breast epithelial progenitors (IF: 8.4). Breast Cancer Res. 2020, 2020 Sep 29;22(1):102. doi: 10.1186/s13058-020-01344-0.
  •  Barrio-Hernandez I, Jafari A, Rigbolt KTG, Hallenborg P, Sanchez-Quiles V, Skovrind I, Akimov V, Kratchmarova I, Dengjel J, Kassem M, Blagoev B. Phosphoproteomic profiling reveals a defined genetic program for osteoblastic lineage commitment of human bone marrow-derived stromal stem cells (IF: 12.0). Genome Res. 2020 Jan;30(1):127-137.
  •  Jafari A, Isa A, Chen L, Ditzel N, Zaher W, Harkness L, Johnsen HE, Abdallah BM, Clausen C, Kassem M. TAFA2 induces skeletal (stromal) stem cell migration through activation of Rac1-p38 signaling (IF: 6.0). Stem Cells. 2019 Mar;37(3):407-416.
  •  Jafari A, Qanie D, Andersen TL, Zhang L, Chen L, Postert B, Parsons S, Ditzel N, Khosla S, Johansen HT, Kjærsgaard-Andersen P, Delaisse JM, Abdallah BM, Hesselson D, Solberg R, Kassem M. Legumain regulates differentiation fate of human bone marrow stromal cells and is altered in postmenopausal osteoporosis (IF: 7.2). Stem Cell Reports. 2017 Feb 14;8(2):373-386.




Our current international collaborators are from:

  • Maine Medical Center (USA)
  • Garvan Institute (Australia)
  • University of Oslo (Norway)
  • University of Cambridge (UK)
  • Ludwig-Maximillian-University, Munich (Germany)



We are always looking for motivated master students for research projects. Please contact us at ajafari@sund.ku.dk




Our current funding sources are:

  • Novo Nordisk Foundation
  • Olav Thon Foundation
  • Gigtforeningen




Group Leader

 foto af abbasAbbas Jafari Kermani
Associate Professor of Bone Biology

(+45) 35 33 74 23
CV, publications, etc for Abbas Jafari Kermani



Morphogenesis and Differentiation Program