Marja Jäättelä

Dr. Jäättelä’s main research interests include the role of lysosomes and autophagy in cancer progression, alternative cell death pathways, maintenance of lysosomal membrane integrity, lipid metabolism and lipid storage disorders.

The translational part of Dr. Jäättelä’s present research focuses on developing clinically relevant acid sphingomyelinase inhibiting cationic amphiphilic drugs for cancer treatment.

• Nielsen IØ, Groth-Pedersen L, Dicroce-Giacobini J, Jonassen ASH, Mortensen M, Bilgin M, Schmiegelow K, Jäättelä M, Maeda K: Cationic amphiphilic drugs induce elevation in lysoglycerophospholipid levels and cell death in leukemia cells. Metabolomics 2020;16(9):91
• Holland LKK, Nielsen IØ, Maeda K, Jäättelä M: Snapshot: Lysosomal functions. Cell 2020;181(3):748
• Nielsen IØ, Vidas Olsen A, Dicroce-Giacobini J, Papaleo E, Andersen KK, Jäättelä M, Maeda K, Bilgin M: Comprehensive Evaluation of a Quantitative Shotgun Lipidomics Platform for Mammalian Sample Analysis on a High-Resolution Mass Spectrometer. J Am Soc Mass Spectrom 2020;31(4):894-907
• Bilgin M, Nylandsted J, Jäättelä M, Maeda K: Quantitative profiling of lysosomal lipidome by shotgun lipidomics. Methods Mol.Biol 2017;1594:19-34
• Maeda K, Poletto M, Chiapparino A, Gavin AC: A generic protocol for the purification and characterization of water-soluble complexes of affinity-tagged proteins and lipids. Nat Protoc 2014;9(9):2256-2266
• Maeda K, Anand K, Chiapparino A, Kumar A, Poletto M, Kaksonen M, Gavin AC: Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins. Nature 2013;501(7466):257-261